T cell receptor excision circles (TRECs) in relation to acute cardiac allograft rejection

T cell receptor excision circles (TRECs) in relation to acute cardiac allograft rejection

Autor Morgun, A. Google Scholar
Shulzhenko, N. Google Scholar
Socorro-Silva, A. Google Scholar
Diniz, RVZ Google Scholar
Almeida, D. R. Google Scholar
Gerbase-Delima, M. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo The purpose of this study was to quantify T cell receptor excision circles (TRECs) in blood mononuclear cells of cardiac transplant recipients and to investigate a possible relationship between TREC levels and rejection episodes. in addition, we investigated the correlation of TREC levels with age and also compared the levels between transplant recipients and healthy individuals. TREC levels were assessed by quantitative competitive PCR in 70 blood samples from 27 graft recipients and in 66 blood samples from 66 healthy individuals. the results showed: (1) higher TREC levels during rejection than during rejection-free periods (medians 9.0 vs. 0.3; p<0.001); (2) no suggestion of correlation with doses of prednisone or time after transplantation; (3) a negative correlation between TREC levels and age; and (4) lower TREC levels in cardiac recipients than in age-matched healthy controls. the value of blood TREC level measurements as an approach to rejection monitoring warrants future investigation.
Palavra-chave T cell receptor excision circles
acute cardiac rejection
naive T cells
transplantation
Idioma Inglês
Data de publicação 2004-11-01
Publicado em Journal of Clinical Immunology. New York: Kluwer Academic/plenum Publ, v. 24, n. 6, p. 612-616, 2004.
ISSN 0271-9142 (Sherpa/Romeo, fator de impacto)
Publicador Kluwer Academic/plenum Publ
Extensão 612-616
Fonte http://dx.doi.org/10.1007/s10875-004-6246-1
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000225962800004
Endereço permanente http://repositorio.unifesp.br/handle/11600/28000

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