Stockpiling of transitional and classic primary follicles in ovaries of women with polycystic ovary syndrome

Stockpiling of transitional and classic primary follicles in ovaries of women with polycystic ovary syndrome

Autor Maciel, Gustavo Arantes Rosa Autor UNIFESP Google Scholar
Baracat, Edmund Chada Autor UNIFESP Google Scholar
Benda, Jo Ann Google Scholar
Markham, Sanford M. Google Scholar
Hensinger, Krista Google Scholar
Chang, R. Jeffrey Google Scholar
Erickson, Gregory F. Google Scholar
Instituição Univ Calif San Diego
Universidade Federal de São Paulo (UNIFESP)
Univ Iowa
Resumo Recently, we proposed an oocyte-growth differentiation factor-9 hypothesis that predicts alterations in the initial stages of folliculogenesis in polycystic ovary syndrome (PCOS) ovaries. Here, we test this hypothesis by scoring the composition of follicles in normal and PCOS ovaries. Follicles were classified as primordial, transitional primary, classic primary, secondary, and Graafian. A total of 2274 follicles were scored. the total number of growing follicles was significantly greater in PCOS ovaries than normal, but the number of nongrowing primordial follicles did not differ. Consequently, the increase in growing follicles in PCOS cannot be explained by increased primordial follicle recruitment. Differential counts showed that the number of growing follicles at each stage of development was significantly greater: PCOS had 2.7-fold more primary, 1.8-fold more secondary, and 2-fold more Graafian follicles than normal. the greatest effect was on the classic primary follicles where the number was almost 5-fold greater in PCOS ovaries. the absence of apoptosis in normal and PCOS preantral follicles argues that the increase in growing follicles in PCOS cannot be explained by changes in atresia. We conclude, therefore, that primary follicle growth is abnormally slow in PCOS and the dynamics are reflected in a stockpiling of classic primary follicles.
Idioma Inglês
Data de publicação 2004-11-01
Publicado em Journal of Clinical Endocrinology & Metabolism. Chevy Chase: Endocrine Soc, v. 89, n. 11, p. 5321-5327, 2004.
ISSN 0021-972X (Sherpa/Romeo, fator de impacto)
Publicador Endocrine Soc
Extensão 5321-5327
Fonte http://dx.doi.org/10.1210/jc.2004-0643
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000224946300007
Endereço permanente http://repositorio.unifesp.br/handle/11600/27994

Exibir registro completo




Arquivo

Arquivo Tamanho Formato Visualização

Não existem arquivos associados a este item.

Este item está nas seguintes coleções

Buscar


Navegar

Minha conta