Peptide dissociation in solution or bound to a polymer: comparative solvent effect

Peptide dissociation in solution or bound to a polymer: comparative solvent effect

Autor Malavolta, L. Google Scholar
Nakaie, C. R. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Dissociation of peptide when in solution or attached to a polymer was investigated. Magnified solvation of peptide-resins occurred in solvent with similar polarity. Conversely the solubilization of peptides was not usually directly related to the medium polarity. the greater the difference between acidity and basicity of solvent and its potential to form van der Waals interaction, the stronger its solubilization strength. Solvents with similar electrophilicity and nucleophilicity usually did not solvate aggregated peptide-resins nor dissolve peptides. the peptide solubilization in water-containing mixed solvents depended on combination of acidity/basicity of both components. Some criteria for choosing suitable solvents for peptide-resin solvation or peptide solubilization could be advanced. (C) 2004 Elsevier B.V. All rights reserved.
Palavra-chave peptide
polymer
solubility
polarity
solvent
Idioma Inglês
Data de publicação 2004-10-11
Publicado em Tetrahedron. Oxford: Pergamon-Elsevier B.V., v. 60, n. 42, p. 9417-9424, 2004.
ISSN 0040-4020 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 9417-9424
Fonte http://dx.doi.org/10.1016/j.tet.2004.08.013
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000224234500007
Endereço permanente http://repositorio.unifesp.br/handle/11600/27979

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