Histologic evolution of bone disease 6 months after successful kidney transplantation

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dc.contributor.author Cruz, EAS
dc.contributor.author Lugon, JR
dc.contributor.author Jorgetti, V
dc.contributor.author Draibe, S. A.
dc.contributor.author Carvalho, A. B.
dc.date.accessioned 2016-01-24T12:37:25Z
dc.date.available 2016-01-24T12:37:25Z
dc.date.issued 2004-10-01
dc.identifier http://dx.doi.org/10.1053/j.ajkd.2004.06.022
dc.identifier.citation American Journal of Kidney Diseases. Philadelphia: W B Saunders Co, v. 44, n. 4, p. 747-756, 2004.
dc.identifier.issn 0272-6386
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/27972
dc.description.abstract Background: the histologic patterns of bone disease, as well as the evolution of renal osteodystrophy after kidney transplantation (Tx), are not well defined. Information in this regard is scarce and contradictory. Methods: Before and 6 months after Tx, analysis of biochemical, hormonal, and bone histomorphometric parameters were performed. Twenty patients (14 men and 6 women) entered the study. Median age was 36.5 (range, 20 to 55) years, and median time on dialysis was 22 (9 to 88) months. Results: Bone histomorphometric diagnoses at pre-Tx were adynamic bone disease, 12; mixed bone disease, 3; mild disease, 3; and osteitis fibrosa, 2. After Tx, 11 had adynamic bone disease; 8, mild disease; and 1, osteomalacia. As a whole, dynamic parameters improved significantly in patients who had adynamic bone. Five of the 12 with this diagnosis completely recovered their bone turnover. Pre-Tx hyperparathyroldism bone features improved or resolved, but 5 of the 8 patients had low-turnover bone disease (adynamic disease, 4; osteomalacia, 1). Three of them had persistence of aluminum and/or iron deposits on bone surface, and the other 2 had hypophosphatemia and high intact parathyroid hormone levels. Overall, biochemical parameters tended toward normalization. Serum intact parathyroid hormone before Tx was correlated negatively with post-Tx trabecular thickness. Conclusion: Six months after Tx, bone histology remained abnormal. the high turnover bone disease improved in all cases, but in most of them low turnover bone disease emerged. Nearly half of the cases with pre-Tx adynamic bone disease recovered their bone turnover completely with some improvement observed in the majority of the remaining cases. en
dc.format.extent 747-756
dc.language.iso eng
dc.publisher W B Saunders Co
dc.relation.ispartof American Journal of Kidney Diseases
dc.rights Acesso restrito
dc.subject bone biopsy en
dc.subject renal osteodystrophy en
dc.subject kidney transplantation en
dc.subject adynamic bone disease en
dc.subject hyperparathyroidism bone disease en
dc.subject low-turnover bone disease en
dc.title Histologic evolution of bone disease 6 months after successful kidney transplantation en
dc.type Artigo
dc.contributor.institution Universidade Federal Fluminense (UFF)
dc.contributor.institution Universidade de São Paulo (USP)
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Univ Fed Fluminense, Div Nephrol, Dept Internal Med, Rio de Janeiro, Brazil
dc.description.affiliation Univ São Paulo, Div Nephrol, Dept Internal Med, São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Div Nephrol, Dept Internal Med, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Div Nephrol, Dept Internal Med, São Paulo, Brazil
dc.identifier.doi 10.1053/j.ajkd.2004.06.022
dc.description.source Web of Science
dc.identifier.wos WOS:000224473400020



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