Interleukin-1 beta polymorphisms, Helicobacter pylori infection in individuals from Northern Brazil with gastric adenocarcinoma

Interleukin-1 beta polymorphisms, Helicobacter pylori infection in individuals from Northern Brazil with gastric adenocarcinoma

Autor Gatti, L. L. Google Scholar
Burbano, R. R. Google Scholar
Assumpcao, P. P. de Google Scholar
Smith, MDC Google Scholar
Payao, SLM Google Scholar
Instituição FAMEMA
Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Fed Univ Para
Resumo Gastric carcinogenesis is a complex, multistep process, which may be influenced by many factors and is the second most common type of malignancy and the second most-common cause of mortality in the word. Interleukin-1 is up-regulated in the presence of Helicobacter pylori and is important for initiating and amplifying the inflammatory response to this infection. Recently interleukin-1 polymorphisms have been associated with the development of gastric adenocarcinoma. in this study we investigated the presence of H. pylori and host genotypes that are highly associated with gastric alterations. DNA samples were extracted and PCR-RFLP was utilized for genotyping IL-1B (-511) polymorphisms, PCR-VNTR was utilized for genotyping IL-1RN, and PCR-CTPP was utilized for genotyping IL-1B (-31), the presence of H. pylori was detected by the urease test. Our results indicate a correlation between H. pylori infection and the development of gastric cancer. We did not find an association between the presence of genotype T (thymine) in bases -511 and -31 and gastric adenocarcinoma. We also did not find any association between this polymorphism and specific type of tumor (diffuse type and intestinal type).
Palavra-chave Helicobacter pylori
interleukin-1 beta polymorphisms
gastric cancer
Idioma Inglês
Data de publicação 2004-10-01
Publicado em Clinical and Experimental Medicine. New York: Springer, v. 4, n. 2, p. 93-98, 2004.
ISSN 1591-8890 (Sherpa/Romeo, fator de impacto)
Publicador Springer
Extensão 93-98
Fonte http://dx.doi.org/10.1007/s10238-004-0043-2
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000224836400005
Endereço permanente http://repositorio.unifesp.br/handle/11600/27957

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