Examination of the SGCE gene in Tourette's syndrome patients with obsessive-compulsive disorder

Examination of the SGCE gene in Tourette's syndrome patients with obsessive-compulsive disorder

Autor Aguiar, P. D. Google Scholar
Fazzari, M. Google Scholar
Jankovic, J. Google Scholar
Ozelius, L. J. Google Scholar
Instituição Albert Einstein Coll Med
Universidade Federal de São Paulo (UNIFESP)
Baylor Coll Med
Resumo Mutations in the E-sarcoglycan gene (SGCE) have been reported in families with myoclonus-dystonia (M-D). in addition to abnormal movements, obsessive- compulsive disorder (OCD) has also been described in families with M-D. OCD is a common feature in another movement disorder, namely Tourette's syndrome (TS). the comorbidity of these disorders suggests that common genetic factors might be involved in their susceptibility. To evaluate this, we performed two sets of experiments. An association study using a polymorphism within an intron of the SGCE gene was assessed in patients with TS and OCD versus controls, and the SGCE gene itself was screened for mutations in all TS/OCD patients, followed by direct sequencing of the gene in a limited number of these patients. No correlation was found by either method. (C) 2004 Movement Disorder Society.
Palavra-chave myoclonus-dystonia
epsilon-sarcoglycan
Tourette's syndrome
obsessive-compulsive disorder
Idioma Inglês
Data de publicação 2004-10-01
Publicado em Movement Disorders. Hoboken: Wiley-liss, v. 19, n. 10, p. 1237-1238, 2004.
ISSN 0885-3185 (Sherpa/Romeo, fator de impacto)
Publicador Wiley-Blackwell
Extensão 1237-1238
Fonte http://dx.doi.org/10.1002/mds.20156
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000224422000017
Endereço permanente http://repositorio.unifesp.br/handle/11600/27955

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