Protective effect of ifenprodil against spreading depression in the mouse entorhinal cortex

Protective effect of ifenprodil against spreading depression in the mouse entorhinal cortex

Autor Faria, Leonardo Coutinho Autor UNIFESP Google Scholar
Mody, Istvan Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Univ Calif Los Angeles
Resumo In the brain, spreading depression (SD) is characterized by a large extracellular DC shift, a massive failure of ion homeostasis and a transient cessation of neuronal function. Clinically, SD is believed to be involved in various neurological disorders including migraine and cerebrovascular diseases. the propagation of cortical SD requires the release of glutamate, and N-methyl-D-aspartate ( NMDA) receptors play a crucial role in this process. Here, we have isolated the NMDA receptor-mediated component of extracellularly recorded field excitatory postsynaptic potentials (fEPSPs) in layers 2 - 3 of the entorhinal cortex of murine brain slices. in the absence of GABA(A) and AMPA receptor-mediated synaptic transmission, stimulation of layer 6 afferents every 15 - 90 s elicited spontaneous SD on average within 18.5 min after the start of the stimulation. in the presence of ifenprodil, an NR2B receptor subunit-selective NMDA receptor antagonist, the occurrence of SD was nearly abolished. Our results are consistent with an important role of NR2B subunits in triggering SD in the entorhinal cortex.
Idioma Inglês
Data de publicação 2004-10-01
Publicado em Journal of Neurophysiology. Bethesda: Amer Physiological Soc, v. 92, n. 4, p. 2610-2614, 2004.
ISSN 0022-3077 (Sherpa/Romeo, fator de impacto)
Publicador Amer Physiological Soc
Extensão 2610-2614
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000223954500059
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