Epidemiology and molecular analysis of herpes simplex keratitis requiring primary penetrating keratoplasty

Epidemiology and molecular analysis of herpes simplex keratitis requiring primary penetrating keratoplasty

Autor Branco, Bruno C. Autor UNIFESP Google Scholar
Gaudio, P. A. Google Scholar
Margolis, T. P. Google Scholar
Instituição Univ Calif San Francisco
Universidade Federal de São Paulo (UNIFESP)
Yale Univ
Resumo Aims: To determine whether herpes simplex keratitis (HSK) has declined as an indication for penetrating keratoplasty (PKP) at the University of California San Francisco (UCSF) over the past 30 years.Methods: Records of the Hogan Eye Pathology Laboratory were reviewed to determine the incidence of PKP performed for HSK from 1972 through 2001. Archived corneal tissue with the diagnosis of HSK was evaluated for herpes simplex virus (HSV) DNA by polymerase chain reaction (PCR) based assays.Results: the number of corneal buttons submitted with the clinical diagnosis of HSK decreased from 1972 to 2001, while the overall number of PKPs performed did not. the percentage of corneal buttons with a clinical diagnosis of HSK that contained detectable HSV DNA did not change over the course of the study period.Conclusion: HSK declined as an indication for PKP from 1972 to 2001 at UCSF. It is unlikely that this decline was the result of improved diagnostic accuracy since detection of HSV DNA in corneal buttons with a clinical diagnosis of HSK was similar at the beginning and end of the study period.
Idioma Inglês
Data 2004-10-01
Publicado em British Journal of Ophthalmology. London: B M J Publishing Group, v. 88, n. 10, p. 1285-1288, 2004.
ISSN 0007-1161 (Sherpa/Romeo, fator de impacto)
Editor B M J Publishing Group
Extensão 1285-1288
Fonte http://dx.doi.org/10.1136/bjo.2003.040162
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000223951100015
URI http://repositorio.unifesp.br/handle/11600/27951

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