Diurnal variation in the genital reflexes and hormone levels induced by paradoxical sleep deprivation and cocaine in male rats

Diurnal variation in the genital reflexes and hormone levels induced by paradoxical sleep deprivation and cocaine in male rats

Autor Andersen, M. L. Google Scholar
Papale, L. A. Google Scholar
Tufik, S. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo The purpose was to ascertain whether the genital reflexes induced by paradoxical sleep deprivation (PSD) in male rats show diurnal variation, and whether the hormonal rhythm of testosterone and progesterone is involved in these behaviors. Genital reflexes (penile erection - PE, and ejaculation - EJ) and hormone levels were assessed during a 24 h period at four testing times (0900, 1600, 2 100 and 0400 h) in PSD rats injected with saline or cocaine. Results indicated that PE in PSD rats given saline or cocaine did not show diurnal variation while EJ responses were significantly reduced at 0400 h in the PSD-cocaine group. the home-cage control group testosterone concentrations were lower at 1600, 2100 and 0400 h than at 0900 h. At 0900 h, testosterone levels were significantly lower in the PSD groups than in the control group. in contrast, progesterone levels were significantly higher in PSD groups in relation to the control group at the four testing times. Thus, we observed strong diurnal variation in testosterone and progesterone in control rats whereas only EJ responses in PSD-cocaine seemed to be influenced by the time of day. These results suggest that progesterone may influence the modulation of male genital reflexes displayed by sleep-deprived rats. (C) 2004 Elsevier Inc. All rights reserved.
Palavra-chave sleep
drug of abuse
sexual behavior
testosterone
progesterone
Idioma Inglês
Data de publicação 2004-09-30
Publicado em Brain Research Bulletin. Oxford: Pergamon-Elsevier B.V., v. 64, n. 3, p. 215-220, 2004.
ISSN 0361-9230 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 215-220
Fonte http://dx.doi.org/10.1016/j.brainresbull.2004.07.007
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000224523200003
Endereço permanente http://repositorio.unifesp.br/handle/11600/27943

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