Low ethanol concentrations selectively augment the tonic inhibition mediated by delta subunit-containing GABA(A) receptors in hippocampal neurons

Low ethanol concentrations selectively augment the tonic inhibition mediated by delta subunit-containing GABA(A) receptors in hippocampal neurons

Autor Wei, Weizheng Z. Google Scholar
Faria, Leonardo Coutinho Autor UNIFESP Google Scholar
Mody, Istvan Google Scholar
Instituição Univ Calif Los Angeles
Universidade Federal de São Paulo (UNIFESP)
Resumo In central neurons, a tonic conductance is activated by ambient levels of the inhibitory transmitter GABA. Here, we show that in dentate gyrus granule cells, where tonic inhibition is mediated by delta subunit-containing GABA(A) receptors, this conductance is augmented by low concentrations (30 mM) of ethanol. in contrast, the tonic inhibition mediated by alpha5 subunit-containing receptors of CA1 pyramidal cells is not affected. the effect of ethanol on tonic inhibition specifically reduces the excitability of the dentate gyrus and identifies the delta subunit-dependent tonic inhibition as a likely site of ethanol action in the brain.
Palavra-chave alcohol
CA1
dentate
GABA
hippocampus
inhibition
Idioma Inglês
Data de publicação 2004-09-22
Publicado em Journal of Neuroscience. Washington: Soc Neuroscience, v. 24, n. 38, p. 8379-8382, 2004.
ISSN 0270-6474 (Sherpa/Romeo, fator de impacto)
Publicador Soc Neuroscience
Extensão 8379-8382
Fonte http://dx.doi.org/10.1523/JNEUROSCI.2040-04.2004
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000224009600020
Endereço permanente http://repositorio.unifesp.br/handle/11600/27942

Exibir registro completo




Arquivo

Arquivo Tamanho Formato Visualização

Não existem arquivos associados a este item.

Este item está nas seguintes coleções

Buscar


Navegar

Minha conta