The good and the bad effects of (-)-trans-delta-9-tetrahydrocannabinol (Delta(9)-THC) on humans

The good and the bad effects of (-)-trans-delta-9-tetrahydrocannabinol (Delta(9)-THC) on humans

Author Carlini, E. A. Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract This review analyses the therapeutic usefulness of Delta(9)-tetrahydrocannabinol and its potential to induce adverse reactions on humans. During the last 30 years an enormous amount of research was carried out resulting in the disclosure of the cannabinoid system in Central Nervous System, with its CB1 and CB2 receptors, and the agonist anandamide. Under the clinical point of view, Delta(9)-THC produces some therapeutic benefits which are beyond reasonable doubt. Thus, the effects on nausea/emesis due to cancer chemotherapy, as appetite promoter, on some painful conditions and on symptoms of multiple sclerosis are clearly demonstrated.Delta(9)-THC is not devoid of ill effects. On the cognitive domain it impairs the human capacity to discriminate time intervals and space distances, vigilance, memory and the performance for mental work. On the psychic area Delta(9)-THC may induce unpleasant reactions such as disconnected thoughts, panic reactions, disturbing changes in perception, delusions and hallucinatory experiences. However, the long term effects on the psyche and cognition are not known as there are no reports of prolonged use of Delta(9)-THC. Actually, it has been proposed by WHO that Delta(9)-THC should be rescheduled to schedule IV of the United Nations Convention on Psychotropic Drugs, as it does not constitute a substantial risk to public health and its abuse is rare if at all. (C) 2004 Published by Elsevier B.V.
Keywords Delta(9)-THC
dronabinol dependence
abstinence
multiple sclerosis
nausea and vomiting
appetite promoter
Language English
Date 2004-09-15
Published in Toxicon. Oxford: Pergamon-Elsevier B.V., v. 44, n. 4, p. 461-467, 2004.
ISSN 0041-0101 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 461-467
Origin http://dx.doi.org/10.1016/j.toxicon.2004.05.009
Access rights Closed access
Type Review
Web of Science ID WOS:000223654600010
URI http://repositorio.unifesp.br/handle/11600/27941

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