Cross-sectional study of abnormal amygdala development in adolescents and young adults with bipolar disorder

Cross-sectional study of abnormal amygdala development in adolescents and young adults with bipolar disorder

Autor Chen, B. K. Google Scholar
Sassi, R. Google Scholar
Axelson, D. Google Scholar
Hatch, J. P. Google Scholar
Sanches, M. Google Scholar
Nicoletti, M. Google Scholar
Brambilla, P. Google Scholar
Keshavan, M. S. Google Scholar
Ryan, N. D. Google Scholar
Birmaher, B. Google Scholar
Soares, J. C. Google Scholar
Instituição Univ Texas
Univ Pittsburgh
Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
IRCCS
S Texas Vet Hlth Care Syst
Resumo Background: in vivo imaging studies in adult bipolarpatients have suggested enlargement of the amygdala. It is not known whether this abnormality is already present early in the illness course or whether it develops later in life. We conducted a morphometric MRI study to examine the size of specific temporal lobe structures in adolescents and young adults with bipolar disorder and healthy control subjects, as well as their relationship with age, to examine possible neurodevelopmental abnormalities.Methods: Subjects included 16 DSM-IV bipolarpatients (16 +/- 3 years) and 21 healthy controls (mean age SD = 17 +/- 4 years). Measures of amygdala, bippocampus, temporal gray matter, temporal lobe, and intracranial volumes (ICV) were obtained.Results: There was a trend to smaller left amygdala volumes inpatients (mean volumes +/- SD = 1.58 +/- .42 mL) versus control subjects (1.83 +/- .4 mL; F = 3.87, df = 1,32, p =.06). Bipolar patients did not show significant differences in right or left bippocampus, temporal lobe gray matter, temporal lobe, or right amygdala volumes (analysis of covariance, age, gender, and JCV as covariates, p >.05) compared with healthy control subjects. Furthermore, there was a direct correlation between left amygdala volumes and age (r =.50, p =.047) in patients, whereas in healthy controls there was an inverse correlation (r = -. 48, p =.03).Conclusions: the direct correlation between left amygdala volumes and age in bipolar patients, not present in healthy control subjects, may reflect abnormal developmental mechanisms in bipolar disorder,
Palavra-chave adolescence
affective disorders
development
mood disorders
MRI
neuroimaging
Idioma Inglês
Data de publicação 2004-09-15
Publicado em Biological Psychiatry. New York: Elsevier B.V., v. 56, n. 6, p. 399-405, 2004.
ISSN 0006-3223 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 399-405
Fonte http://dx.doi.org/10.1016/j.biopsych.2004.06.024
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000223855200004
Endereço permanente http://repositorio.unifesp.br/handle/11600/27938

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