Frequency of antinuclear antibodies in healthy children and adolescents

Frequency of antinuclear antibodies in healthy children and adolescents

Autor Hilario, MOE Google Scholar
Len, C. A. Google Scholar
Roja, S. C. Google Scholar
Terreri, M. T. Google Scholar
Almeida, G. Google Scholar
Andrade, LEC Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Sera from 214 healthy children and adolescents (108 females [50.4%]) aged 6 months to 20 years (mean 8.7 years) and from 116 patients with rheumatic diseases were assayed for antinuclear antibody (ANA) by indirect immunofluorescence (1117) by using HEp-2 cells as substrate. Twenty-seven healthy children (12.6%) presented a positive ANA test; there was no difference between genders, and we observed a trend for higher frequency of ANA greater than or equal to 1/80 among children between 5 years and 10 years. Eight of the 27 healthy children with positive ANA test were reevaluated 36 months later, and none of them had developed any rheumatic disease, though the sera remained positive in 2 of them. ANA was present in 42/116 patients (36.2%). in daily medical practice ANA determination should be required only in individuals with clinical signs and symptoms suggestive of autoimmune disease.
Idioma Inglês
Data de publicação 2004-09-01
Publicado em Clinical Pediatrics. Glen Head: Westminster Publ Inc, v. 43, n. 7, p. 637-642, 2004.
ISSN 0009-9228 (Sherpa/Romeo, fator de impacto)
Publicador Westminster Publ Inc
Extensão 637-642
Fonte http://dx.doi.org/10.1177/000992280404300709
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000224081700009
Endereço permanente http://repositorio.unifesp.br/handle/11600/27934

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