Serotonin reuptake inhibitors in auditory processing disorders in elderly patients: Preliminary results

Show simple item record

dc.contributor.author Cruz, OLM
dc.contributor.author Kasse, C. A.
dc.contributor.author Sanchez, M.
dc.contributor.author Barbosa, F.
dc.contributor.author Barros, F. A.
dc.date.accessioned 2016-01-24T12:37:22Z
dc.date.available 2016-01-24T12:37:22Z
dc.date.issued 2004-09-01
dc.identifier http://dx.doi.org/10.1097/00005537-200409000-00029
dc.identifier.citation Laryngoscope. Philadelphia: Lippincott Williams & Wilkins, v. 114, n. 9, p. 1656-1659, 2004.
dc.identifier.issn 0023-852X
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/27927
dc.description.abstract Objective/Hypothesis. One mechanism associated with degeneration in the elderly is the decrease of neurotransmitters. in the central auditory pathway serotonin, can be found from cochlear nucleus to the auditory cortex, and it constitutes one of the most important neuromodudatory circuits in hearing processing. the present study analyzed the action of citalopram, a selective inhibitor of serotonin reuptake, in aged patients with normal to moderate sensorineural hearing loss (HL) and low performance on auditory processing. Study Design/Method: Prospective, double-blind, randomized, placebo-controlled study. Thirty-eight selected patients were randomly divided into two groups. Nineteen patients made up group A and received placebo for 60 days. Nineteen patients of Group B received 20 mg per day of citalopram for 60 days. Hearing evaluation was performed initially and after 60 days and included pure-tone audiometry, speech discrimination test (SDT), emittanciometry (acoustic impedance audiometry), identification of synthetic sentences with an ipsilateral competitive message (SSI/ICM), tests of pitch-pattern sequences (PPS), and the staggered spondaic words test (SSW). Results. Comparisons of tests of auditory processing pre- and posttreatment in each group showed a statistical improvement in performance on all tests in group B after 2 months of therapy. Comparisons pre- and posttreatment between groups showed that patients who received citalopram presented statistically significantly better results in the SSI/ICM test (P <.0001) after treatment. the same comparison in results for the PPS test and the SSW test revealed a tendency (P =.09 and 0.058, respectively) toward better performance in the group receiving citalopram. Conclusion: These preliminary results suggest that the use of citalopram can have a positive impact on auditory processes in elderly patients with low performance in auditory process. en
dc.format.extent 1656-1659
dc.language.iso eng
dc.publisher Lippincott Williams & Wilkins
dc.relation.ispartof Laryngoscope
dc.rights Acesso restrito
dc.subject serotonin reuptake inhibitors en
dc.subject auditory processing en
dc.subject auditory pathways en
dc.subject elderly en
dc.title Serotonin reuptake inhibitors in auditory processing disorders in elderly patients: Preliminary results en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo UNIFESP, Dept Otolaryngol, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo UNIFESP, Dept Otolaryngol, São Paulo, Brazil
dc.identifier.doi 10.1097/00005537-200409000-00029
dc.description.source Web of Science
dc.identifier.wos WOS:000224314800029



File

File Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search


Browse

Statistics

My Account