Factors associated with optic disc hemorrhages in glaucoma

Factors associated with optic disc hemorrhages in glaucoma

Autor Soares, A. S. Google Scholar
Artes, P. H. Google Scholar
Andreou, P. Google Scholar
Leblanc, R. P. Google Scholar
Chauhan, B. C. Google Scholar
Nicolela, M. T. Google Scholar
Instituição Dalhousie Univ
Universidade Federal de São Paulo (UNIFESP)
Resumo Purpose: To evaluate factors associated with optic disc hemorrhages (ODHs) in patients with open-angle glaucoma.Design: Cohort study.Participants: One hundred thirty-seven patients with open-angle glaucoma, with an initial mean age of 60.0 years (standard deviation [SD], 11.0 years) followed up for a mean of 9.5 years (SD, 5.0 years).Methods: the association between ODHs and various patient-related variables (diabetes, systemic hypertension, heart disease, hypercholesterolemia, migraine, hypothyroidism, use of platelet antiaggregant agents) and eye-related variables (mean and range of intraocular pressure, refractive error, and severity of disease) was investigated using multivariate time-to-event analyses in patients with open-angle glaucoma. To determine the influence of the level of intraocular pressure (IOP) on the occurrence of ODHs, we compared the IOP at the time the first ODH was noted with the mean IOP of the previous 3 visits. As a control, a similar analysis was performed on the same eyes using a randomly selected visit before the occurrence of the first ODH.Main Outcome Measurements: Patient-related and eye-related variables associated with ODHs and the comparative level of IOP in which these ODHs were observed.Results: Fifty eyes of 38 patients (28%) had 1 or more ODHs during the follow-up period. the ODHs were associated with presence of diabetes (hazard ratio, 4.43; 95% confidence interval [CI], 1.8-10.50; P = 0.001) and use of aspirin (hazard ratio, 2.30; 95% CI, 1.2-4.6; P = 0.019). the IOP at the time of the first ODH was, on average, 1.4 mmHg lower than the mean IOP of the 3 previous visits (95% CI, -2.2 to -0.6 mmHg; P<0.001), whereas in the control analysis, the respective value was 0.3 mmHg lower (95% CI, -1.0 to 0.5; P = 0.410).Conclusions: Optic disc hemorrhages were associated with diabetes and aspirin use and were observed at relatively lower IOP during follow-up. (C) 2004 by the American Academy of Ophthalmology.
Idioma Inglês
Data 2004-09-01
Publicado em Ophthalmology. New York: Elsevier B.V., v. 111, n. 9, p. 1653-1657, 2004.
ISSN 0161-6420 (Sherpa/Romeo, fator de impacto)
Editor Elsevier B.V.
Extensão 1653-1657
Fonte http://dx.doi.org/10.1016/j.ophtha.2004.03.023
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000223606300007
URI http://repositorio.unifesp.br/handle/11600/27921

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