Evaluation of fluconazole resistance mechanisms in Candida albicans clinical isolates from HIV-infected patients in Brazil

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dc.contributor.author Goldman, G. H.
dc.contributor.author Ferreira, MED
dc.contributor.author Marques, E. D.
dc.contributor.author Savoldi, M.
dc.contributor.author Perlin, D.
dc.contributor.author Park, S.
dc.contributor.author Martinez, PCG
dc.contributor.author Goldman, MHS
dc.contributor.author Colombo, A. L.
dc.date.accessioned 2016-01-24T12:37:21Z
dc.date.available 2016-01-24T12:37:21Z
dc.date.issued 2004-09-01
dc.identifier http://dx.doi.org/10.1016/j.diagmicrobio.2004.04.009
dc.identifier.citation Diagnostic Microbiology and Infectious Disease. New York: Elsevier B.V., v. 50, n. 1, p. 25-32, 2004.
dc.identifier.issn 0732-8893
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/27912
dc.description.abstract In this study, we describe resistance mechanisms in fluconazole-resistant isolates of C albicans isolated from AIDS patients from nine Brazilian hospitals. These mechanisms include the presence of point mutations in the ERG11 gene and overexpression of ERG11, and several genes encoding efflux pumps, as measured by quantitative real-time reverse transcriptase polymerase chain reaction. Several fluconazole-resistant strains had multiple mechanisms of resistance. Four mutations previously described, Y132F, K143R, E266D, and V4371, were identified among the strains, whereas some isolates contained more than one mutation. Fourteen novel mutations were identified. Interestingly, all Brazilian fluconazole-resistant isolates showed homozygosity at mating-type loci (MTL) associated with fluconazole resistance. This is the first comprehensive assessment at molecular level of mechanisms of fluconazole resistance in C albicans isolates from South America. (C) 2004 Elsevier Inc. All rights reserved. en
dc.format.extent 25-32
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Diagnostic Microbiology and Infectious Disease
dc.rights Acesso restrito
dc.title Evaluation of fluconazole resistance mechanisms in Candida albicans clinical isolates from HIV-infected patients in Brazil en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Universidade de São Paulo (USP)
dc.contributor.institution Publ Hlth Res Inst
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Univ São Paulo, Fac Ciencias Farmaceut Ribeirao Preto, BR-05508 São Paulo, Brazil
dc.description.affiliation Publ Hlth Res Inst, New York, NY USA
dc.description.affiliation Universidade Federal de São Paulo, Div Infect Dis, São Paulo, Brazil
dc.description.affiliation Univ São Paulo, Fac Filosofia Ciencias & Letras Ribeirao Pret, BR-05508 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Div Infect Dis, São Paulo, Brazil
dc.identifier.doi 10.1016/j.diagmicrobio.2004.04.009
dc.description.source Web of Science
dc.identifier.wos WOS:000224226200004



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