Lymphocytic inflammation in childhood bronchiolitis obliterans

Lymphocytic inflammation in childhood bronchiolitis obliterans

Autor Mauad, T. Google Scholar
van Schadewijk, A. Google Scholar
Schrumpf, J. Google Scholar
Hack, C. E. Google Scholar
Fernezlian, S. Google Scholar
Garippo, A. L. Google Scholar
Ejzenberg, B. Google Scholar
Hiemstra, P. S. Google Scholar
Rabe, K. F. Google Scholar
Dolhnikoff, M. Google Scholar
São Paulo BO Study Grp Google Scholar
Instituição Universidade de São Paulo (USP)
Leiden Univ
Netherlands Red Cross
Free Univ Amsterdam
Universidade Federal de São Paulo (UNIFESP)
São Paulo Pediat Assoc
Resumo Childhood bronchiolitis obliterans (CBO) is an infrequent, severe disorder characterized by persistent obstructive respiratory symptoms after an acute episode of bronchiolitis. the viral etiology is most common, and adenovirus is the most frequently identified causative agent. Pathologically, the disease is characterized as constrictive type BO, with variable degrees of chronic inflammation and fibrosis in the bronchioles. the nature of the cellular infiltrate is largely unknown, and its characterization may provide better understanding of the disease and offer clues for therapy. Therefore, the aim of the present study was to characterize the inflammatory infiltrate in the bronchioles of 23 open lung biopsies of children with CBO and to compare this to the infiltrate in histologically normal airways. Our results show that CD3+ T cells were the most frequent cell type observed in CBO, with a predominance of the CD8+ T-cell subtype. When compared to the control group, there was a larger number of CD8+, CD4+, CD20+, granzyme B+, and perforin+ lymphocytes in the CBO group. Further studies are needed to address the role of different cell types in the development of CBO.
Palavra-chave bronchioles
lung pathology
bronchiolitis obliterans
children
lymphocytes
immunohistochemistry
open lung biopsy
Idioma Inglês
Data de publicação 2004-09-01
Publicado em Pediatric Pulmonology. Hoboken: Wiley-liss, v. 38, n. 3, p. 233-239, 2004.
ISSN 8755-6863 (Sherpa/Romeo, fator de impacto)
Publicador Wiley-Blackwell
Extensão 233-239
Fonte http://dx.doi.org/10.1002/ppul.20064
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000223391200010
Endereço permanente http://repositorio.unifesp.br/handle/11600/27904

Exibir registro completo




Arquivo

Arquivo Tamanho Formato Visualização

Não existem arquivos associados a este item.

Este item está nas seguintes coleções

Buscar


Navegar

Minha conta