An intravitreal biodegradable sustained release naproxen and 5-fluorouracil system for the treatment of experimental post-traumatic proliferative vitreoretinopathy

An intravitreal biodegradable sustained release naproxen and 5-fluorouracil system for the treatment of experimental post-traumatic proliferative vitreoretinopathy

Autor Cardillo, J. A. Google Scholar
Farah, M. E. Autor UNIFESP Google Scholar
Mitre, J. Google Scholar
Morales, P. H. Google Scholar
Costa, R. A. Google Scholar
Melo, LAS Google Scholar
Kuppermann, B. Google Scholar
Jorge, R. Google Scholar
Ashton, P. Google Scholar
Instituição Hosp Olhos Araraquara
Universidade Federal de São Paulo (UNIFESP)
Univ Calif Irvine
Tufts New England Med Ctr
Resumo Background/aims: To determine the potential of an intravitreal sustained release naproxen and 5-fluorouracil (NA/5-FU) codrug for the treatment of experimental proliferative vitreoretinopathy (PVR) in a model for trauma associated tractional retinal detachment (TRD).Methods: Sustained release pellets were prepared by covalently linking naproxen to 5-fluorouracil. Drug release was tested in vitro and toxic effects were evaluated by electroretinography and light microscopy. Traumatic PVR was induced in pigmented rabbits by performing a scleral laceration, followed by repair and intravitreal injection of 0.4 ml of autologous blood. Thirty six eyes were treated with a sustained release implant containing 1.5 mg NA/5-FU as a codrug and 36 control eyes were submitted to surgery alone. Eyes were evaluated for TRD by serial indirect ophthalmoscope examination at different time points followed by postmortem fundus evaluation of the enucleated eyeResults: the NA/5-FU pellets were found to provide linear release of 5-FU and naproxen over the 30 day duration of the in vitro release test. Both the severity of PVR grade and the percentage of eyes with moderate or worse tractional detachment were significantly lower in eyes treated with the codrug pellet. There were no drug related toxic effects evident on histopathological or electroretinograph examination of eyes containing the NA/5-FU pellet.Conclusions: the results suggest that this NA/5-FU codrug device effectively inhibits the progression of PVR in a rabbit trauma model that closely resembles PVR in humans. Additional studies to add knowledge to these initial findings and to clarify the potential of the codrug device for the treatment of human PVR are warranted.
Idioma Inglês
Data de publicação 2004-09-01
Publicado em British Journal of Ophthalmology. London: B M J Publishing Group, v. 88, n. 9, p. 1201-1205, 2004.
ISSN 0007-1161 (Sherpa/Romeo, fator de impacto)
Publicador B M J Publishing Group
Extensão 1201-1205
Fonte http://dx.doi.org/10.1136/bjo.2003.039917
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000223355700022
Endereço permanente http://repositorio.unifesp.br/handle/11600/27900

Exibir registro completo




Arquivo

Arquivo Tamanho Formato Visualização

Não existem arquivos associados a este item.

Este item está nas seguintes coleções

Buscar


Navegar

Minha conta