Resistance trends of Acinetobacter spp. in Latin America and characterization of international dissemination of multi-drug resistant strains: five-year report of the SENTRY Antimicrobial Surveillance Program

Resistance trends of Acinetobacter spp. in Latin America and characterization of international dissemination of multi-drug resistant strains: five-year report of the SENTRY Antimicrobial Surveillance Program

Autor Tognim, Maria Cristina Bronharo Autor UNIFESP Google Scholar
Andrade, Soraya Sgambatti Autor UNIFESP Google Scholar
Silbert, Suzane Autor UNIFESP Google Scholar
Gales, Ana Cristina Autor UNIFESP Google Scholar
Jones, Ronald N. Google Scholar
Sader, Helio Silva Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Universidade Estadual de Maringá (UEM)
Jones Grp
Resumo Objectives: To analyze the antimicrobial susceptibility of Acinetobacter spp. isolates collected from Latin American medical centers as part of the SENTRY Antimicrobial Surveillance Program and also to evaluate the dissemination of mutti-drug resistant Acinetobacter spp. strains in the region.Methods: A total of 826 isolates of Acinetobacter spp. from multiple infection sites were collected from January 1997 to December 2001 in ten medical centers and susceptibility tested to >25 selected agents by broth microdilution. Multi-drug resistant Acinetobacter spp. isolates were molecular typed.Results: Resistance rates to carbapenems varied significantly among countries. A continued annual increase occurred in the Argentinean medical centers. in contrast, carbapenem resistance was rare in Chilean centers, and decreased significantly in the Brazilian institutions. Acinetobacter spp. isolates recovered from lower respiratory tract and bloodstream infections were associated with lower antimicrobial susceptibility rates. Resistance rates to imipenem were higher among isolates collected from intensive care units (13.5%) than among isolates from other units. A major ribogroup pattern (521-1) was detected among eight Acinetobocter spp. strains isolated from three distinct Latin American countries.Conclusions: This study found that antimicrobial resistance is still a major issue among Acinetobacter spp. isolates collected from some Latin American countries. the dissemination of a major bacterial cluster in different regions reinforces the importance of longitudinal surveillance programs, such as SENTRY, as valuable tools for monitoring antimicrobial susceptibility rates and guiding local interventions. (C) 2004 International Society for Infectious Diseases. Published by Elsevier B.V. All rights reserved.
Palavra-chave Acinetobacter
antimicrobial resistance
carbapenem resistance
Latin America
polymyxin
SENTRY
Idioma Inglês
Data de publicação 2004-09-01
Publicado em International Journal of Infectious Diseases. Oxford: Elsevier B.V., v. 8, n. 5, p. 284-291, 2004.
ISSN 1201-9712 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 284-291
Fonte http://dx.doi.org/10.1016/j.ijid.2003.11.009
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000223966900009
Endereço permanente http://repositorio.unifesp.br/handle/11600/27897

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