Status epilepticus induced by pilocarpine and Ca2+ transport by microsome in the hippocampus of rats

Status epilepticus induced by pilocarpine and Ca2+ transport by microsome in the hippocampus of rats

Autor Costa, M. S. Google Scholar
Funke, M. G. Google Scholar
Meis, L. de Google Scholar
Cavalheiro, E. A. Google Scholar
Naffah-Mazzacoratti, M. D. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
UNIVAP
Universidade Federal do Rio de Janeiro (UFRJ)
Resumo An increase in intra-neuronal Ca2+ concentration has been associated to status epilepticus (SE). Ca2+ is stored in the endoplasmic reticulum, mediated by the Ca2+-ATPases (SERCAs). Here we studied the Ca2+-ATPase activity and the SERCA2b distribution in the hippocampus of rats submitted to 5 h of SE. the Ca2+-uptake was measured using [Ca-45]CaCl2 and the hippocampal distribution of SERCA2b was analyzed by immunohistochemistry. A reduction in the amount of cells expressing SERCA2b in CA1, CA3 and dentate gyrus was observed. However, the surviving cells of these regions increased the SERCA2b immunoreactivity, when compared with control tissues. the Ca2+-ATPase activity measured in all hippocampal formation was not modified by SE. These results suggest that SE promotes a redistribution of SERCA2b in the hippocampus as a compensatory Ca2+-transport mechanism. (C) 2004 Elsevier Ireland Ltd. All fights reserved.
Assunto pilocarpine
microsome
hippocampus
Ca2+-ATPase
epilepsy
Idioma Inglês
Data 2004-08-19
Publicado em Neuroscience Letters. Clare: Elsevier Sci Ireland Ltd, v. 366, n. 3, p. 292-296, 2004.
ISSN 0304-3940 (Sherpa/Romeo, fator de impacto)
Editor Elsevier B.V.
Extensão 292-296
Fonte http://dx.doi.org/10.1016/j.neulet.2004.05.052
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000223438400014
URI http://repositorio.unifesp.br/handle/11600/27887

Mostrar registro completo




Arquivos deste item

Arquivos Tamanho Formato Visualização

Não existem arquivos associados a este item.

Este item aparece na(s) seguinte(s) coleção(s)