Effects of androgen manipulation on alpha(1)-adrenoceptor subtypes in the rat seminal vesicle

Effects of androgen manipulation on alpha(1)-adrenoceptor subtypes in the rat seminal vesicle

Autor Mendes, F. R. Google Scholar
Hamamura, M. Google Scholar
Queiroz, DBC Google Scholar
Porto, C. S. Google Scholar
Avellar, MCW Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo This study analyses possible changes during surgical and chemical castration in the expression and pharmacological characteristics of alpha(1)-adrenoceptor in adult rat seminal vesicle. Ribonuclease protection assays indicated that alpha(1a)- was the predominant mRNA, while alpha(1b)- and alpha(1d)-adrenoceptor transcripts were detected in lower abundance in this tissue. alpha(1a)-adrenoceptor mRNA expression presented a complex dependency on androgens, while alpha(1b)- and alpha(1d)-adrenoceptor transcripts were both upregulated with surgical and chemical castration, suggesting a negative modulation by androgens. Testosterone treatment reversed the effects caused by surgical castration. Functional studies confirmed the involvement of alpha(1A)- and alpha(1B)-adrenoceptor in the seminal vesicle contractile responses, and suggested that alpha(1B)-induced contractile response was upregulated after castration. Taken together, the results suggest that alpha(1)-adrenoceptor expression in seminal vesicle is differentially regulated by the androgen status of the rat. (C) 2004 Elsevier Inc. All rights reserved.
Palavra-chave seminal vesicle
alpha(1)-adrenoceptor
castration
androgen
Idioma Inglês
Data de publicação 2004-08-06
Publicado em Life Sciences. Oxford: Pergamon-Elsevier B.V., v. 75, n. 12, p. 1449-1463, 2004.
ISSN 0024-3205 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 1449-1463
Fonte http://dx.doi.org/10.1016/j.lfs.2004.03.011
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000222873600004
Endereço permanente http://repositorio.unifesp.br/handle/11600/27884

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