Low clinical stage renal cell carcinoma: Relevance of microvascular tumor invasion as a prognostic parameter

Low clinical stage renal cell carcinoma: Relevance of microvascular tumor invasion as a prognostic parameter

Autor Goncalves, P. D. Google Scholar
Srougi, M. Google Scholar
Dall'Oglio, M. F. Google Scholar
Leite, KRM Google Scholar
Ortiz, V Google Scholar
Hering, F. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Hosp Sirio Libanes
Resumo Purpose: Renal cell carcinoma is a tumor with unpredictable behavior and defining reliable prognostic factors would be extremely valuable in the clinical setting. Tumor stage, nuclear grade and tumor cell type are the main prognostic clinical parameters available. in this study we evaluated the role of microvascular involvement in the primary lesion for predicting tumor behavior in patients with low stage clinical disease.Materials and Methods: A total of 95 patients with clinically localized renal cell carcinoma (stages T-1-T-2 N-x M-0) underwent radical nephrectomy and/or nephron sparing surgery, and were followed for a median of 45 months. the impact of microvascular tumor invasion on disease progression and its correlation with known pathological outcomes (tumor size, nuclear grade and cell type) were studied.Results: Microvascular tumor invasion was observed in 24 patients (25%), of whom 50% had disease recurrence. of the 71 patients without microvascular invasion only 4 (6%) showed tumor recurrence. When microvascular invasion was correlated with other histological parameters, a significant statistical association was noted with tumor diameter, perirenal fat invasion, macroscopic extension to the renal vein, nuclear grade, lymph node metastasis and sarcomatous elements in the tumor. Multivariate analysis showed that microvascular invasion and the involvement of regional lymph nodes were independent predictors of disease recurrence. Concerning cancer specific survival, microvascular invasion and perirenal fat infiltration were the only factors related to death.Conclusions: Microvascular invasion is an independent and relevant clinical prognostic parameter for low clinical stage renal cell carcinoma.
Palavra-chave kidney
carcinoma
renal cell
prognosis
neoplasm invasiveness
neoplasms
vascular tissue
Idioma Inglês
Data de publicação 2004-08-01
Publicado em Journal of Urology. Philadelphia: Lippincott Williams & Wilkins, v. 172, n. 2, p. 470-474, 2004.
ISSN 0022-5347 (Sherpa/Romeo, fator de impacto)
Publicador Lippincott Williams & Wilkins
Extensão 470-474
Fonte http://dx.doi.org/10.1097/01.ju.0000130582.31467.30
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000222639300010
Endereço permanente http://repositorio.unifesp.br/handle/11600/27870

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