A polymorphism in the promoter of UCP2 gene modulates lipid levels in patients with type 2 diabetes

A polymorphism in the promoter of UCP2 gene modulates lipid levels in patients with type 2 diabetes

Autor Reis, A. F. Google Scholar
Dubois-Laforgue, D. Google Scholar
Bellanne-Chantelot, C. Google Scholar
Timsit, J. Google Scholar
Velho, G. Google Scholar
Instituição Hop St Vincent de Paul
Universidade Federal de São Paulo (UNIFESP)
Hop Cochin
Hop St Antoine
Resumo A G/A single nucleotide polymorphism (SNP) in the position -866 of the UCP2 promoter modulates UCP2 expression in adipose tissue and pancreatic beta-cell, and is associated with variations of body mass index (BMI) and insulin secretion in nondiabetic subjects. We investigated associations of this SNP with traits related to obesity, dyslipidemia, and hyperglycemia in patients with type 2 diabetes. the -866 G/A SNP in the UCP2 promoter was genotyped by PCR/RFLP in 681 type 2 diabetic patients. Increased triglyceride (greater than or equal to1.70mM), total cholesterol (greater than or equal to6.0mM) and LDL-cholesterol (greater than or equal to3.35mM) levels were significantly less frequent in homozygous carriers of the G-allele than in homozygous carriers of the A-allele. Odds ratios for the risk of dyslipidemia in GG vs AA carriers were 0.45, 0.57, and 0.50, for triglyceride, total cholesterol and LDL-cholesterol, respectively (all p < 0.007). No genetic effects of this polymorphism on the BMI or on traits related to the severity of hyperglycemia were observed. in conclusion, a common polymorphism in the promoter region of the UCP2 gene modulates triglycerides and cholesterol levels in French Caucasian subjects with type 2 diabetes. the implications of this effect in the evolution of type 2 diabetes and its macrovascular complications deserve to be investigated. (C) 2004 Elsevier Inc. All rights reserved.
Palavra-chave UCP2
type 2 diabetes mellitus
dyslipidemia
single nucleotide polymorphism
association studies
Idioma Inglês
Data de publicação 2004-08-01
Publicado em Molecular Genetics and Metabolism. San Diego: Academic Press Inc Elsevier Science, v. 82, n. 4, p. 339-344, 2004.
ISSN 1096-7192 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 339-344
Fonte http://dx.doi.org/10.1016/j.ymgme.2004.06.008
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000223570900010
Endereço permanente http://repositorio.unifesp.br/handle/11600/27860

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