Indocyanine green mediated photothrombosis for the management of predominantly classic choroidal neovascularisation caused by age related macular degeneration

Indocyanine green mediated photothrombosis for the management of predominantly classic choroidal neovascularisation caused by age related macular degeneration

Author Farah, Michel E. Autor UNIFESP Google Scholar
Cardillo, J. A. Google Scholar
Luzardo, A. C. Google Scholar
Calucci, Daniela Autor UNIFESP Google Scholar
Williams, G. A. Google Scholar
Costa, R. A. Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Associated Retinal Consultants
Abstract Aims: To study the effectiveness of indocyanine green mediated photothrombosis in the management of predominantly classic subfoveal choroidal neovascularisation associated with age related macular degeneration.Methods: Prospective, non-comparative, interventional case series of nine patients with predominantly classic subfoveal choroidal neovascularisation secondary to age related macular degeneration who declined photocoagulation or verteporfin photodynamic therapy. Patients were submitted to one or more treatments with an intravenous injection of a small volume of high concentration indocyanine green solution followed by low irradiance, large spot 810 nm continuous laser application via a transpupillary approach. Main outcome measures were change in best corrected visual acuity and macular exudative manifestations.Results: After 12 months of follow up, the final best corrected visual acuity was the same ( plus or minus two ETDRS lines) in five eyes (55%), improved more than two ETDRS lines in three eyes (33%), and worsened by more than two lines in the remaining eye. the improved vision was probably related to partial or complete restoration of the macular architecture as a result of fluid resolution, whereas the worsened vision was primarily the result of treatment failure in achieving substantial choroidal neovascular occlusion. There were no complications related to the procedure.Conclusion: Indocyanine green mediated photothrombosis may be an effective alternative treatment for predominantly classic subfoveal choroidal neovascularisation caused by age related macular degeneration.
Language English
Date 2004-08-01
Published in British Journal of Ophthalmology. London: B M J Publishing Group, v. 88, n. 8, p. 1055-1059, 2004.
ISSN 0007-1161 (Sherpa/Romeo, impact factor)
Publisher B M J Publishing Group
Extent 1055-1059
Origin http://dx.doi.org/10.1136/bjo.2003.035808
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000222727100018
URI http://repositorio.unifesp.br/handle/11600/27845

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