Omiganan pentahydrochloride (MBI 226), a topical 12-amino-acid cationic peptide: Spectrum of antimicrobial activity and measurements of bactericidal activity

Omiganan pentahydrochloride (MBI 226), a topical 12-amino-acid cationic peptide: Spectrum of antimicrobial activity and measurements of bactericidal activity

Autor Sader, Helio S. Autor UNIFESP Google Scholar
Fedler, Kelley A. Google Scholar
Rennie, Robert P. Google Scholar
Stevens, Shelley Google Scholar
Jones, Ronald N. Google Scholar
Instituição JMI Labs
Universidade Federal de São Paulo (UNIFESP)
Univ Alberta Hosp
Resumo The activity of omiganan pentahydrochloride (formerly MBI 226; a synthetic cationic peptide) was assessed against 1,437 recent clinical bacterial isolates and 214 recent clinical yeast isolates. the omiganan was highly active, and minimal bactericidal concentrations or minimal fungicidal concentrations were either equal to or two- to fourfold higher than MICs. Kill curve experiments showed a clear pattern of bactericidal activity.
Idioma Inglês
Data de publicação 2004-08-01
Publicado em Antimicrobial Agents and Chemotherapy. Washington: Amer Soc Microbiology, v. 48, n. 8, p. 3112-3118, 2004.
ISSN 0066-4804 (Sherpa/Romeo, fator de impacto)
Publicador Amer Soc Microbiology
Extensão 3112-3118
Fonte http://dx.doi.org/10.1128/AAC.48.8.312-3118.2004
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000222998300047
Endereço permanente http://repositorio.unifesp.br/handle/11600/27844

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