Alternatives to amphotericin B for Candida rugosa infection

Alternatives to amphotericin B for Candida rugosa infection

Autor Hernandez, S. Google Scholar
Gonzalez, G. M. Google Scholar
McCarthy, D. I. Google Scholar
Colombo, Arnaldo Lopes Autor UNIFESP Google Scholar
Najvar, L. K. Google Scholar
Bocanegera, R. Google Scholar
Graybill, JR Google Scholar
Instituição Univ Texas
Univ Autonoma Nuevo Leon
Universidade Federal de São Paulo (UNIFESP)
Resumo Objective: Amphotericin B failure is frequently seen in patients with candidaemia caused by Candida rugosa. We evaluated amphotericin 13, fluconazole, posaconazole and voriconazole as alternative treatments against infection in mice with two isolates of C. rugosa.Methods: Neutropenic mice were inoculated intravenously with C. rugosa. Amphotericin 13, fluconazole, posaconazole and voriconazole were administered for 7 days after infection. Efficacy of the antifungal treatment was assessed by survival and tissue burden of C. rugosa.Results: All of the four drugs significantly prolonged survival over controls. With both isolates, kidney counts were reduced significantly below controls for amphotericin B, fluconazole and posaconazole. However, voriconazole was less effective than the other antifungals.Conclusion: Despite poor clinical response to amphotericin B, in vivo data indicate that amphotericin B increases organ clearance and survival over untreated controls. However, although voriconazole improved survival over controls, increased tissue clearance was not seen. This discrepancy may be caused by rapid clearance of voriconazole in mice. These studies suggest fluconazole, posaconazole or voriconazole may be useful alternatives to amphotericin B in therapy of C. rugosa infection.
Palavra-chave murine model
antifungals
C. rugosa
Idioma Inglês
Data de publicação 2004-08-01
Publicado em Journal of Antimicrobial Chemotherapy. Oxford: Oxford Univ Press, v. 54, n. 2, p. 477-480, 2004.
ISSN 0305-7453 (Sherpa/Romeo, fator de impacto)
Publicador Oxford Univ Press
Extensão 477-480
Fonte http://dx.doi.org/10.1093/jac/dkh335
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000223372100030
Endereço permanente http://repositorio.unifesp.br/handle/11600/27842

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