Rubella immunization in human immunodeficiency virus type 1-infected children

Rubella immunization in human immunodeficiency virus type 1-infected children

Autor Lima, M. Google Scholar
Succi, RCD Google Scholar
Dos Santos, AMN Google Scholar
Weckx, L. Y. Google Scholar
Moraes-Pinto, M. I. de Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Background: HIV infection can have important although sometimes unexpected consequences, such as contributing to enlargement of the pool of rubella-susceptible children.Methods: At the Federal University of São Paulo, Brazil, we assessed response to rubella immunization at 15 months of age in 15 human immunodeficiency virus type 1 (HIV)-infected children, 20 seroreverted children (SR) and 18 healthy control children born to HIV-seronegative mothers (CON). Blood samples were collected before and 3 months after vaccination. All HIV-infected children had started highly active antiretroviral therapy during their first 6 months of life. Serum samples were tested with a rubella IgG enzyme-linked immunosorbent assay kit.Results: HIV children in immunologic categories 2/3 had lower rubella antibody titers (geometric mean, 33 IU/mL) than those from CON (125 IU/mL) and SR group (236 IU/mL) (Tukey, P = 0.01). Antibody values after vaccination were positively associated with CD4 T cell numbers and negatively associated with HIV viral load assessed immediately before vaccination. the percentage of children with protective antibodies after vaccination (above 10.0 IU/mL) was also significantly different among groups (Fisher's exact test, P = 0.013): CON, 94%; SR, 100%; HIV category 1, 100%; HIV category 2/3, 62%.Conclusions: HIV-infected children with a preserved immune system at measles-mumps-rubella immunization can have a good response to rubella vaccine. in contrast, those in more advanced categories for HIV infection respond poorly.
Palavra-chave rubella eradication
immunization
vertical human
immunodeficiency virus type 1 infection
Idioma Inglês
Data de publicação 2004-07-01
Publicado em Pediatric Infectious Disease Journal. Philadelphia: Lippincott Williams & Wilkins, v. 23, n. 7, p. 604-607, 2004.
ISSN 0891-3668 (Sherpa/Romeo, fator de impacto)
Publicador Lippincott Williams & Wilkins
Extensão 604-607
Fonte http://dx.doi.org/10.1097/01.inf.0000128780.79145.5c
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000222842000002
Endereço permanente http://repositorio.unifesp.br/handle/11600/27832

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