Psychopharmacological assessment of Pfaffia glomerata roots (extract BNT-08) in rodents

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dc.contributor.author Marques, L. C.
dc.contributor.author Galvao, SMP
dc.contributor.author Espinola, E.
dc.contributor.author Dias, R. F.
dc.contributor.author Mattei, R.
dc.contributor.author Oliveira, MGM
dc.contributor.author Carlini, ELD
dc.date.accessioned 2016-01-24T12:37:14Z
dc.date.available 2016-01-24T12:37:14Z
dc.date.issued 2004-07-01
dc.identifier http://dx.doi.org/10.1002/ptr.1500
dc.identifier.citation Phytotherapy Research. Chichester: John Wiley & Sons Ltd, v. 18, n. 7, p. 566-572, 2004.
dc.identifier.issn 0951-418X
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/27813
dc.description.abstract A pharmacological assessment of the standardized extract (BNT-08) of Pfaffia glomerata roots was performed in young mice submitted to acute treatment with several doses (i.p.), in young and old mice submitted to chronic oral treatment for 150 days or with water (control groups) and in old mice at a dose of 100 mg/kg of extract. Acute tests involved an initial screening, spontaneous movements, rota-rod, barbiturate sleeping time and passive avoidance were carried out. the chronic test involved mortality assessment, body weight and learning and memory in a T-maze left/right discrimination test and in the passive avoidance model. of the acute tests only the sleeping time test showed relevant differences between the groups. With the chronic treatment, a relevant decrease of the number of sessions necessary for learning in the group of old mice treated with the extract was evident. A partial reversal of the memory deficit induced by age in the old mice treated with the extract was found in the passive avoidance test. the results suggest that the standardized extract from Pfaffia glomerata roots promoted an increase in both learning and memory of old mice treated in the chronic test. Copyright (C) 2004 John Wiley Sons, Ltd. en
dc.format.extent 566-572
dc.language.iso eng
dc.publisher Wiley-Blackwell
dc.relation.ispartof Phytotherapy Research
dc.rights Acesso restrito
dc.subject Pfaffia glomerata en
dc.subject extract BNT-08 en
dc.subject brazilian ginseng en
dc.subject learning and memory en
dc.subject aged rats en
dc.title Psychopharmacological assessment of Pfaffia glomerata roots (extract BNT-08) in rodents en
dc.type Artigo
dc.rights.license http://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.contributor.institution Universidade Estadual de Maringá (UEM)
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Univ Estadual Maringa, Dept Farm & Farmacol, BR-87020900 Maringa, Parana, Brazil
dc.description.affiliation Escola Paulista Med, Dept Psicobiol, BR-04024002 São Paulo, Brazil
dc.description.affiliationUnifesp Escola Paulista Med, Dept Psicobiol, BR-04024002 São Paulo, Brazil
dc.identifier.doi 10.1002/ptr.1500
dc.description.source Web of Science
dc.identifier.wos WOS:000223286000014



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