Psychopharmacological assessment of Pfaffia glomerata roots (extract BNT-08) in rodents

Psychopharmacological assessment of Pfaffia glomerata roots (extract BNT-08) in rodents

Autor Marques, L. C. Google Scholar
Galvao, SMP Google Scholar
Espinola, E. Google Scholar
Dias, R. F. Google Scholar
Mattei, R. Google Scholar
Oliveira, MGM Google Scholar
Carlini, ELD Google Scholar
Instituição Universidade Estadual de Maringá (UEM)
Universidade Federal de São Paulo (UNIFESP)
Resumo A pharmacological assessment of the standardized extract (BNT-08) of Pfaffia glomerata roots was performed in young mice submitted to acute treatment with several doses (i.p.), in young and old mice submitted to chronic oral treatment for 150 days or with water (control groups) and in old mice at a dose of 100 mg/kg of extract. Acute tests involved an initial screening, spontaneous movements, rota-rod, barbiturate sleeping time and passive avoidance were carried out. the chronic test involved mortality assessment, body weight and learning and memory in a T-maze left/right discrimination test and in the passive avoidance model. of the acute tests only the sleeping time test showed relevant differences between the groups. With the chronic treatment, a relevant decrease of the number of sessions necessary for learning in the group of old mice treated with the extract was evident. A partial reversal of the memory deficit induced by age in the old mice treated with the extract was found in the passive avoidance test. the results suggest that the standardized extract from Pfaffia glomerata roots promoted an increase in both learning and memory of old mice treated in the chronic test. Copyright (C) 2004 John Wiley Sons, Ltd.
Palavra-chave Pfaffia glomerata
extract BNT-08
brazilian ginseng
learning and memory
aged rats
Idioma Inglês
Data de publicação 2004-07-01
Publicado em Phytotherapy Research. Chichester: John Wiley & Sons Ltd, v. 18, n. 7, p. 566-572, 2004.
ISSN 0951-418X (Sherpa/Romeo, fator de impacto)
Publicador Wiley-Blackwell
Extensão 566-572
Fonte http://dx.doi.org/10.1002/ptr.1500
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000223286000014
Endereço permanente http://repositorio.unifesp.br/handle/11600/27813

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