Down-regulation of dendritic cell activation induced by Paracoccidio ides brasiliensis

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dc.contributor.author Ferreira, K. S.
dc.contributor.author Lopes, J. D.
dc.contributor.author Almeida, SR
dc.date.accessioned 2016-01-24T12:37:12Z
dc.date.available 2016-01-24T12:37:12Z
dc.date.issued 2004-06-15
dc.identifier http://dx.doi.org/10.1016/j.imlet.2004.04.005
dc.identifier.citation Immunology Letters. Amsterdam: Elsevier B.V., v. 94, n. 1-2, p. 107-114, 2004.
dc.identifier.issn 0165-2478
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/27794
dc.description.abstract Paracoccidioidomycosis (PCM) endemic in Latin America, is a progressive systemic mycosis caused by Paracoccidioides brasiliensis (Pb). the infection can evolve to different clinical forms that are associated to various degrees of suppressed cell-mediated immunity. With the recognition that DCs are able to initiate response in naive T cells and that they also participate in Th cell education, the present study was undertaken to check whether DCs interact with P. brasiliensis, as well as to elucidate possible mechanisms and consequences of this interaction. Our results indicate that P. brasiliensis infection and purified gp43, its main antigenic component, lead to down-regulation of MHC-II and adhesion properties of immature DCs. the down-regulation was also observed in LPS-induced DC maturation. in addition, an inhibition of IL-12 and TNF-alpha production by both P. brasileinsis or gp43, was observed in LPS-induced DC maturation. These results suggest that protein, released in great amounts by the fungus, might be used, to reduce the effectiveness of the immune response. (C) 2004 Elsevier B.V. All rights reserved. en
dc.format.extent 107-114
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Immunology Letters
dc.rights Acesso restrito
dc.subject Paracoccidioidomycosis (PCM) en
dc.subject immunodominant en
dc.subject granulomatous en
dc.title Down-regulation of dendritic cell activation induced by Paracoccidio ides brasiliensis en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Universidade de São Paulo (USP)
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Univ São Paulo, Fac Ciencias Farmaceut, Dept Anal Clin & Toxicol, BR-05508900 São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, UNIFESP, Dept Microbiol Immunol & Parasitol, BR-04023900 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, UNIFESP, Dept Microbiol Immunol & Parasitol, BR-04023900 São Paulo, Brazil
dc.identifier.doi 10.1016/j.imlet.2004.04.005
dc.description.source Web of Science
dc.identifier.wos WOS:000222819300014



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