Down-regulation of dendritic cell activation induced by Paracoccidio ides brasiliensis

Down-regulation of dendritic cell activation induced by Paracoccidio ides brasiliensis

Author Ferreira, K. S. Google Scholar
Lopes, J. D. Google Scholar
Almeida, SR Google Scholar
Institution Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Abstract Paracoccidioidomycosis (PCM) endemic in Latin America, is a progressive systemic mycosis caused by Paracoccidioides brasiliensis (Pb). the infection can evolve to different clinical forms that are associated to various degrees of suppressed cell-mediated immunity. With the recognition that DCs are able to initiate response in naive T cells and that they also participate in Th cell education, the present study was undertaken to check whether DCs interact with P. brasiliensis, as well as to elucidate possible mechanisms and consequences of this interaction. Our results indicate that P. brasiliensis infection and purified gp43, its main antigenic component, lead to down-regulation of MHC-II and adhesion properties of immature DCs. the down-regulation was also observed in LPS-induced DC maturation. in addition, an inhibition of IL-12 and TNF-alpha production by both P. brasileinsis or gp43, was observed in LPS-induced DC maturation. These results suggest that protein, released in great amounts by the fungus, might be used, to reduce the effectiveness of the immune response. (C) 2004 Elsevier B.V. All rights reserved.
Keywords Paracoccidioidomycosis (PCM)
Language English
Date 2004-06-15
Published in Immunology Letters. Amsterdam: Elsevier B.V., v. 94, n. 1-2, p. 107-114, 2004.
ISSN 0165-2478 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 107-114
Access rights Closed access
Type Article
Web of Science ID WOS:000222819300014

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