Autor |
Ribeiro, RCJ
![]() Sales, VSF ![]() Neves, FDR ![]() Drabe, S. ![]() Brandao-Neto, J. ![]() |
Instituição | Univ Fed Rio Grande Norte Universidade de Brasília (UnB) Universidade Federal de São Paulo (UNIFESP) |
Resumo | Thirteen healthy subjects and 20 hemodialysis patients were studied to observe the delayed hypersensitivity skin tests (DHSTs) and phytohemagglutinin (PHA)-stimulating lymphocyte blastogenesis. Significant differences were observed between the groups. Controls had a higher proportion of positive skin reaction than hemodialysis patients in relation to Escherichia coli (p<0.01) and tuberculin (PPD) (p<0.05). Regarding lymphocyte blastogenesis stimulated by phytohemagglutinin (PHA), cell proliferation was more accentuated in controls than hemodialysis patients (p<0.05). On the other hand, serum zinc was elevated in controls (78 +/- 8 mug/dL) in comparison to hemodialysis patients (71 +/- 33 mug/dL) (p<0.05). of the 20 hemodialysis patients, 8 patients were maintained on long-term hemodialysis before and after zinc therapy, with the aim of studying DHST and PHA-stimulating lymphocyte blastogenesis. There was a significant improvement of DHST response to E. coli antigen after 100 d of zinc treatment (p<0.01), and with the discontinuation of therapy, the DHST responses decreased back to the initial values (p<0.05). Zinc administration also increased the lymphocyte proliferation induced by PHA from 31386 +/- 3974 to 42480 +/- 5242 cpm (mean +/-SD) (p<0.05). These results indicated that zinc therapy improved in vivo and in vitro DHST and lymphocyte function of hemodialysis patients and that its discontinuation suppressed all of the benefits observed. |
Palavra-chave |
zinc
cellular immunity hemodialysis patients controls |
Idioma | Inglês |
Data de publicação | 2004-06-01 |
Publicado em | Biological Trace Element Research. Totowa: Humana Press Inc, v. 98, n. 3, p. 209-217, 2004. |
ISSN | 0163-4984 (Sherpa/Romeo, fator de impacto) |
Publicador | Humana Press Inc |
Extensão | 209-217 |
Fonte |
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Direito de acesso | Acesso restrito |
Tipo | Artigo |
Web of Science | WOS:000221485300002 |
Endereço permanente | http://repositorio.unifesp.br/handle/11600/27790 |
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