Prevalence of previous hepatitis A virus infection in renal transplant patients with hepatitis C: Evidence of persistent anti-hepatitis A virus immune response

Prevalence of previous hepatitis A virus infection in renal transplant patients with hepatitis C: Evidence of persistent anti-hepatitis A virus immune response

Autor Mariya, F. A. Google Scholar
Perez, R. D. Google Scholar
Silva, AEB Google Scholar
Pestana, JOM Google Scholar
Ferraz, MLG Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Data concerning the prevalence of hepatitis A virus (HAV) infection among kidney transplant recipients are scarce. There is little information concerning natural immunity acquired after acute HAV infection. in most renal transplant recipients, anti-HAV antibodies are not detectable after vaccination; it is reasonable to suppose that immunosuppressive therapy interferes with the immunity. the objective of this study was to evaluate, in an endemic area, the prevalence of anti-HAV immunoglobulin (Ig)G in renal transplant recipients with chronic hepatitis C virus (HCV) infection. the prevalence of anti-HAV IgG was assessed in 40 HCV-positive renal transplant recipients. This group showed a 90% prevalence of previous HAV infection. These findings suggest that in an endemic area, the prevalence of previous HAV infection is high, even among immunosuppressed patients. HAV antibodies acquired after natural infection are detectable even after the onset of immunosuppressive therapy. These data should be considered when renal transplant recipients are considered for HAV vaccination. Prevaccination screening of renal transplant recipients must follow the same guidelines as those for immunocompetent subjects.
Idioma Inglês
Data de publicação 2004-06-01
Publicado em Transplantation Proceedings. New York: Elsevier B.V., v. 36, n. 5, p. 1500-1501, 2004.
ISSN 0041-1345 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 1500-1501
Fonte http://dx.doi.org/10.1016/j.transproceed.2004.05.034
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000222713000074
Endereço permanente http://repositorio.unifesp.br/handle/11600/27784

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