Cytokines in recurrent pregnancy loss

Cytokines in recurrent pregnancy loss

Autor Daher, S. Google Scholar
Denardi, KDG Google Scholar
Blotta, MHSL Google Scholar
Mamoni, R. L. Google Scholar
Reck, APM Google Scholar
Camano, L. Google Scholar
Mattar, Rosiane Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Universidade Estadual de Campinas (UNICAMP)
Resumo Cytokines seem to play a critical role in the pathogenesis of unexplained recurrent pregnancy loss (RPL). Th1 cytokines have been shown to exert deleterious effects on pregnancy, inhibiting foetal growth and development. On the other hand, Th2 cytokines have been associated with successful pregnancy. the purpose of this study was to evaluate cytokine production in women with RPL. the studied group comprised 29 women with RPL, with at least three consecutive spontaneous abortions. the control group included 27 women with a history of successful pregnancies and no miscarriage. We determined IL-6 and TNF-alpha production in peripheral blood cultured with LPS, as well as IFN-gamma and TGF-beta induced by PHA stimulation. Cytokines were measured by enzyme-linked immunoabsorbant assay (ELISA) using commercial kits (RD, Amersham-Pharmacia). Mann-Whitney test was applied to compare differences between groups. the level of significance was defined at P < 0.05. We observed significantly higher levels of IFN-gamma (355.8 pg/ml versus 98.0 pg/ml; P = 0.01) and a trend toward increased TNF-alpha production (2410.2 pg/ml versus 1980.2 pg/ml; P = 0.07) in RPL women as compared to controls. in relation to IL-6 and TGF-beta, no significant difference was detected between RPL and control groups. in agreement with experimental observations, our data support the hypothesis of Th1 cytokine involvement in the pathogenesis of RPL. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
Palavra-chave cytokines
pregnancy
miscarriage
Idioma Inglês
Data de publicação 2004-06-01
Publicado em Journal of Reproductive Immunology. Clare: Elsevier Sci Ireland Ltd, v. 62, n. 1-2, p. 151-157, 2004.
ISSN 0165-0378 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 151-157
Fonte http://dx.doi.org/10.1016/j.jri.2003.10.004
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000222729500016
Endereço permanente http://repositorio.unifesp.br/handle/11600/27782

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