Exercise training changes autonomic cardiovascular balance in mice

Exercise training changes autonomic cardiovascular balance in mice

Autor De Angelis, K. Google Scholar
Wichi, R. B. Autor UNIFESP Google Scholar
Jesus, WRA Google Scholar
Moreira, E. D. Google Scholar
Morris, M. Google Scholar
Krieger, E. M. Google Scholar
Irigoyen, M. C. Google Scholar
Instituição Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Univ Sao Judas Tadeu
Wright State Univ
Resumo Experiments were performed to investigate the influence of exercise training on cardiovascular function in mice. Heart rate, arterial pressure, baroreflex sensitivity, and autonomic control of heart rate were measured in conscious, unrestrained male C57/6J sedentary (n = 8) and trained mice (n = 8). the exercise training protocol used a treadmill (1 h/day; 5 days/wk for 4 wk). Baroreflex sensitivity was evaluated by the tachycardic and bradycardic responses induced by sodium nitroprusside and phenylephrine, respectively. Autonomic control of heart rate and intrinsic heart rate were determined by use of methylatropine and propranolol. Resting bradycardia was observed in trained mice compared with sedentary animals [ 485 +/- 9 vs. 612 +/- 5 beats/min (bpm)], whereas mean arterial pressure was not different between the groups (106 +/- 2 vs. 108 +/- 3 mmHg). Baroreflex-mediated tachycardia was significantly enhanced in the trained group (6.97 +/- 0.97 vs. 1.6 +/- 0.21 bpm/mmHg, trained vs. sedentary), whereas baroreflex- mediated bradycardia was not altered by training. the tachycardia induced by methylatropine was significantly increased in trained animals (139 +/- 12 vs. 40 +/- 9 bpm, trained vs. sedentary), whereas the propranolol effect was significantly reduced in the trained group (49 +/- 11 vs. 97 +/- 11 bpm, trained vs. sedentary). Intrinsic heart rate was similar between groups. in conclusion, dynamic exercise training in mice induced a resting bradycardia and an improvement in baroreflex- mediated tachycardia. These changes are likely related to an increased vagal and decreased sympathetic tone, similar to the exercise response observed in humans.
Palavra-chave bradycardia
autonomic nervous system
baroreflex
blood pressure
Idioma Inglês
Data de publicação 2004-06-01
Publicado em Journal of Applied Physiology. Bethesda: Amer Physiological Soc, v. 96, n. 6, p. 2174-2178, 2004.
ISSN 8750-7587 (Sherpa/Romeo, fator de impacto)
Publicador Amer Physiological Soc
Extensão 2174-2178
Fonte http://dx.doi.org/10.1152/japplphysiol.00870.2003
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000221296600022
Endereço permanente http://repositorio.unifesp.br/handle/11600/27774

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