Pathogen-specific risk factors and protective factors for acute diarrheal illness in children aged 12-59 months in São Paulo, Brazil

Pathogen-specific risk factors and protective factors for acute diarrheal illness in children aged 12-59 months in São Paulo, Brazil

Author Sobel, J. Google Scholar
Gomes, Tania Aparecida Tardelli Autor UNIFESP Google Scholar
Ramos, Sonia Regina Testa da Silva Autor UNIFESP Google Scholar
Hoekstra, M. Google Scholar
Rodrigue, D. Google Scholar
Rassi, V. Autor UNIFESP Google Scholar
Griffin, P. M. Google Scholar
Institution Ctr Dis Control & Prevent
Universidade Federal de São Paulo (UNIFESP)
Abstract Diarrheal diseases are a leading cause of childhood morbidity and mortality in Latin America. Most studies have focused on infants but not on older children. We enrolled 505 children (age, 12-59 months) with diarrhea and age-matched controls in a case-control study in São Paulo, Brazil. Independent risk factors for diarrhea included another household member with diarrhea (matched odds ratio [mOR], 8.1; attributable fraction [AF], 0.17; P < .001) and consumption of homemade juice (mOR, 1.8; AF, 0.10; P = .01); protective factors included boiling of the baby bottle or nipple (mOR, 0.60; AF, 0.19; P = .026), childcare at home (mOR, 0.58; AF, 0.12; P = .004), and piped sewage ( mOR, 0.58; AF, 0.05;). Hand washing by the caretaker after helping the child defecate protected against Shigella infection (mOR, 0.35; P < .05). Preparation of rice, beans, or soup in the morning and serving it to children after noon were associated with enterotoxigenic Escherichia coli infection (mOR, 8.0; P < .05). in these poor households, 28% of cases of diarrhea in 1-4-year-old children was attributable to easily modifiable exposures.
Language English
Date 2004-06-01
Published in Clinical Infectious Diseases. Chicago: Univ Chicago Press, v. 38, n. 11, p. 1545-1551, 2004.
ISSN 1058-4838 (Sherpa/Romeo, impact factor)
Publisher Univ Chicago Press
Extent 1545-1551
Origin http://dx.doi.org/10.1086/420822
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000221477400006
URI http://repositorio.unifesp.br/handle/11600/27768

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