Dual role of polymorphonuclear neutrophils on the growth of Ehrlich ascites tumor (EAT) in mice

Dual role of polymorphonuclear neutrophils on the growth of Ehrlich ascites tumor (EAT) in mice

Autor Bergami-Santos, P. C. Google Scholar
Mariano, M. B. Google Scholar
Barbuto, JAM Google Scholar
Instituição Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Resumo We show that granulocytes (PMN) have a dual role in the development of Ehrlich Ascites Tumor (EAT) in mice. EAT intraperitoneal inoculation causes a local inflammatory reaction, ascites development and mortality that distinguish resistant and susceptible strains. in resistant mice (CAF1), there is a less pronounced PMN influx after EAT inoculation than in susceptible Swiss mice. Accordingly, the increase in peritoneal PMN numbers enhanced tumor growth in CAR mice, but had no effect in the susceptible Swiss animals. Contrastingly, PMN depletion had no effect in resistant mice but facilitated tumor growth in susceptible animals. Though no differences were noted between the strains in peritoneal cell spreading and hydrogen peroxide release after tumor inoculation, in vitro PMN cytotoxic activity against EAT was significantly higher in susceptible Swiss mice. These data indicate a paradoxical dual role for PMN against EAT: while they help control tumor development in susceptible animals, they seem to enhance tumor growth in resistant mice. (C) 2004 Elsevier Inc. All rights reserved.
Palavra-chave Ehrlich ascites tumor
inflammation
polymorphonuclear cells
PMN
antigranulocyte-antibody RB6-8C5
Idioma Inglês
Data de publicação 2004-05-28
Publicado em Life Sciences. Oxford: Pergamon-Elsevier B.V., v. 75, n. 2, p. 245-255, 2004.
ISSN 0024-3205 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 245-255
Fonte http://dx.doi.org/10.1016/j.lfs.2004.02.003
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000221319100011
Endereço permanente http://repositorio.unifesp.br/handle/11600/27764

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