A novel inexpensive murine model of oral chronic digitalization

A novel inexpensive murine model of oral chronic digitalization

Autor Helber, I Google Scholar
Kanashiro, R. M. Google Scholar
Alarcon, E. A. Google Scholar
Antonio, E. L. Google Scholar
Tucci, PJF Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo 1. A novel inexpensive murine model of oral administration of digitoxin (100 mug/kg per day) added to routine chow is described.2. Serum digitoxin levels achieved after oral (n = 5; 116 +/- 14 ng/mL) and subcutaneous (n = 5; 124 +/- 11 ng/mL) administration were similar.3. A significant increase in the maximal left ventricular pressure rise of treated (it = 9) compared with control (n = 6) rats (dP,dt: 8956 +/- 233 vs 7980 +/- 234 mmHg/s, respectively; P = 0.01) characterized the positive inotropic action of digitoxin. in addition, no differences were observed in treated compared with control rats with regard to the electrocardiogram and systolic and diastolic left ventricular pressures.
Assunto chronic digitalization
oral digitoxin
Idioma Inglês
Data 2004-05-01
Publicado em Clinical and Experimental Pharmacology and Physiology. Carlton: Blackwell Publishing Asia, v. 31, n. 5-6, p. 365-366, 2004.
ISSN 0305-1870 (Sherpa/Romeo, fator de impacto)
Editor Blackwell Publishing Asia
Extensão 365-366
Fonte http://dx.doi.org/10.1111/j.1440-1681.2004.04009.x
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000222184200016
URI http://repositorio.unifesp.br/handle/11600/27762

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