Impact of long-term administration of amiodarone on the thyroid function of patients with Chagas' disease

Impact of long-term administration of amiodarone on the thyroid function of patients with Chagas' disease

Autor Silva, JR Google Scholar
Guariento, M. E. Google Scholar
Fernandes, G. A. Google Scholar
Maciel, R. M. Google Scholar
Ward, L. S. Google Scholar
Instituição Universidade Estadual de Campinas (UNICAMP)
Universidade Federal de São Paulo (UNIFESP)
Resumo The effect of long-term treatment with amiodarone on patients with Chagas' disease has seldom been reported. This nonrandomized observational study attempted to analyze the follow-up of patients with Chagas' disease regarding their clinical evolution, thyroid dysfunction, and goiter. We compared 72 patients with long-term use (11 +/- 5 years) of amiodarone, including 22 patients who developed goiter, to 33 patients who did not use amiodarone, followed-up for 2 to 20 years (7 +/- 11 years). Follow-up of 72 patients for 9 +/- 5.4 years with periodic cardiac and thyroid function evaluations showed that only 26 maintained normal serum thyrotropin (TSH) levels; 24 presented with elevated levels; 4 had low levels, and 18 patients presented with fluctuations of TSH level. Among the 22 patients with goiter, only 3 (14%) patients maintained normal TSH, 8 (36%) had elevated TSH, 2 (9%) had low TSH, and 9 (41%) patients presented with fluctuating serum TSH levels. Most individuals remained clinically euthyroid with no evidence of cardiac impairment that could be attributed to thyroid dysfunction and the arrhythmias were adequately controlled by amiodarone. We suggest that amiodarone treatment may be continued for patients with Chagas' disease with arrhythmias, even in those who develop thyroid function abnormalities or goiter.
Idioma Inglês
Data de publicação 2004-05-01
Publicado em Thyroid. Larchmont: Mary Ann Liebert Inc Publ, v. 14, n. 5, p. 371-377, 2004.
ISSN 1050-7256 (Sherpa/Romeo, fator de impacto)
Publicador Mary Ann Liebert Inc Publ
Extensão 371-377
Fonte http://dx.doi.org/10.1089/105072504774193212
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000221775100008
Endereço permanente http://repositorio.unifesp.br/handle/11600/27759

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