Monosialoganglioside increases catalase activity in cerebral cortex of rats

Monosialoganglioside increases catalase activity in cerebral cortex of rats

Autor Fighera, M. R. Google Scholar
Bonini, J. S. Google Scholar
Frussa, R. Google Scholar
Dutra, C. S. Google Scholar
Hagen, MEK Google Scholar
Rubin, M. A. Google Scholar
Mello, C. F. Google Scholar
Instituição Universidade Federal de Sergipe (UFS)
Universidade Federal de São Paulo (UNIFESP)
Univ Fed Rio Grande Sul
Resumo Monosialoganglioside (GM1) is a neuroprotective agent that has been reported to scavenge free radicals generated during reperfusion and to protect receptors and enzymes from oxidative damage. However, only a few studies have attempted to investigate the effects of GM1 on enzymatic antioxidant defenses of the brain. in the present study, we evaluate the effects of the systemic administration of GM1 on the activity of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px), and on spontaneous chemiluminescence and total radical-trapping potential (TRAP) in cerebral cortex of rats ex vivo . the effects of GM1 on CAT activity and spontaneous chemiluminescence in vitro were also determined.Animals received two injections of GM1 (50 mg/kg, i.p.) or saline (0.85% NaCl, i.p.) spaced 24 h apart. Thirty minutes after the second injection the animals were sacrificed and enzyme activities and spontaneous chemiluminescence and TRAP were measured in cell-free homogenates. GM1 administration reduced spontaneous chemiluminescence and increased catalase activity ex vivo , but had no effect on TRAP, SOD or GSH-Px activities. GM1, at high concentrations, reduced CAT activity in vitro . We suggest that the antioxidant activity of GM1 ganglioside in the cerebral cortex may be due to an increased catalase activity.
Assunto GM1 ganglioside
total radical-trapping antioxidant potential
antioxidant enzymes
spontaneous chemiluminescence
Idioma Inglês
Data 2004-05-01
Publicado em Free Radical Research. Abingdon: Taylor & Francis Ltd, v. 38, n. 5, p. 495-500, 2004.
ISSN 1071-5762 (Sherpa/Romeo, fator de impacto)
Editor Taylor & Francis Ltd
Extensão 495-500
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000220959400009

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