Multifocal and full-field electroretinogram changes associated with color-vision loss in mercury vapor exposure

Multifocal and full-field electroretinogram changes associated with color-vision loss in mercury vapor exposure

Autor Ventura, D. F. Google Scholar
Costa, MTV Google Scholar
Costa, M. F. Google Scholar
Berezovsky, Adriana Autor UNIFESP Google Scholar
Salomão, Solange Rios Autor UNIFESP Google Scholar
Simoes, A. L. Google Scholar
Lago, M. Google Scholar
Pereira, LHMC Google Scholar
Faria, MAM Google Scholar
De Souza, J. M. Google Scholar
Silveira, LCL Google Scholar
Instituição Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Fed Univ Para
Resumo We evaluated the color vision of mercury-contaminated patients and investigated possible retinal origins of losses using electroretinography. Participants were retired workers from a fluorescent lamp industry diagnosed with mercury contamination (n = 43) and age-matched controls (n = 21). Color discrimination was assessed with the Cambridge Colour Test (CCT). Retinal function was evaluated by using the ISCEV protocol for full-field electroretinography (full-field ERG), as well as by means of multifocal electroretinography (mfERG). Color-vision losses assessed by the CCT consisted of higher color-discrimination thresholds along the protan, deutan, and tritan axes and significantly larger discrimination ellipses in mercury-ex posed patients compared to controls. Full-field ERG amplitudes from patients were smaller than those of the controls for the scotopic response b-wave, maximum response, sum of oscillatory potentials (OPs), 30-Hz flicker response, and light-adapted cone response. OP amplitudes measured in patients were smaller than those of controls for O2 and O3. Multifocal ERGs recorded from ten randomly selected patients showed smaller N1-P1 amplitudes and longer latencies throughout the 25-deg central field. Full-field ERGs showed that scotopic, photopic, peripheral, and midperipheral retinal functions were affected, and the mfERGs indicated that central retinal function was also significantly depressed. To our knowledge, this is the first demonstration of retinal involvement in visual losses caused by mercury toxicity.
Assunto ERG
color vision
mercury toxicity
Idioma Inglês
Data 2004-05-01
Publicado em Visual Neuroscience. New York: Cambridge Univ Press, v. 21, n. 3, p. 421-429, 2004.
ISSN 0952-5238 (Sherpa/Romeo, fator de impacto)
Editor Cambridge Univ Press
Extensão 421-429
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000224547200038

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