A comparative study of MMP-2 in vulvar neoplasms

A comparative study of MMP-2 in vulvar neoplasms

Autor Bovo, A. C. Google Scholar
Silva, IDCG da Google Scholar
Takita, L. C. Google Scholar
Fochi, J. Google Scholar
Stavale, J. N. Google Scholar
Marks, G. Google Scholar
Lima, G. R. de Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Objective. To investigate differences in MMP-2 protein expression in VIN, vulvar invasive carcinoma, and lichen sclerosus, we performed an immunohistochemical study in which tissue samples from individuals affected by these conditions were compared with normal vulvar tissue. 'Methods. A total of 57 cases were selected, as follows: 14 cases of vulvar invasive carcinoma, 22 of vulvar intraepithelial neoplasia (6 of VIN I, 5 of VIN II, and II of VTN III), 9 of vulvar lichen sclerosus, and 12 samples of normal vulvar tissue. Immunohistochemistry was done with primary monoclonal antibodies against MMP-2 and quantification of the immunostaining was done by counting the number of antigen-positive stromal cells per 1000 stromal cells.Results. Normal vulvar tissue had a median score of 37.99 stromal cells positive for MMP-2. the median scores for VTN I/II and lichen sclerosus were 41.98 and 46.51, respectively, with no statistical differences when compared to the normal group. Invasive cancer had a score statistically higher (160.36) than any of the other groups.Conclusion. Invasive vulvar carcinoma had a score statistically higher of MMP-2 than normal tissue, VIN, and lichen sclerosus. (C) 2004 Elsevier Inc. All rights reserved.
Palavra-chave matrix metalloproteinases
vulva
cancer
vulvar diseases
vulvar neoplasm
Idioma Inglês
Data de publicação 2004-05-01
Publicado em Gynecologic Oncology. San Diego: Academic Press Inc Elsevier Science, v. 93, n. 2, p. 454-457, 2004.
ISSN 0090-8258 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 454-457
Fonte http://dx.doi.org/10.1016/j.ygyno.2004.01.049
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000221120500029
Endereço permanente http://repositorio.unifesp.br/handle/11600/27754

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