Monitoring anti-HLA class I IgG antibodies in renal transplant recipients

Monitoring anti-HLA class I IgG antibodies in renal transplant recipients

Autor Aragao, E. Google Scholar
Moura, L. A. Google Scholar
Pacheco-Silva, A. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Anti-HLA class I IgG antibodies play an important role in hyperacute rejection but the significance of its de novo appearance or increase in levels during the posttransplant period remains controversial. the purpose of this study was to determine the correlation between the anti-HLA class I IgG antibodies and posttransplant events during the first 4 months after renal transplantation. From 200 renal allograft recipients, 549 serum samples were retrospectively evaluated. Patients who experienced graft dysfunction confirmed by biopsy had three serum samples tested: before, during (within 24 hours), and after the event. the presence of anti-HLA antibodies was observed in recipients with chronic allograft nephropathy (60%); acute rejection (clinical criteria without biopsy 57.1%); rejection types IIA (7.1%), IIB (40%), and III (50%); borderline changes (42.8%); acute tubular necrosis (34.4%); infarction (25%); and no rejection (12.5%). We observed a high incidence of anti-HLA class I IgG antibodies during acute tubular necrosis, borderline changes, acute rejection types IIB and III, and chronic allograft nephropathy.
Idioma Inglês
Data de publicação 2004-05-01
Publicado em Transplantation Proceedings. New York: Elsevier B.V., v. 36, n. 4, p. 836-837, 2004.
ISSN 0041-1345 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 836-837
Fonte http://dx.doi.org/10.1016/j.transproceed.2004.03.060
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000222063800012
Endereço permanente http://repositorio.unifesp.br/handle/11600/27743

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