Microchimerism does not correlate with survival of murine cardiac allografts

Microchimerism does not correlate with survival of murine cardiac allografts

Author Moraes, L. V. de Google Scholar
Bueno, V Google Scholar
Panajotopoulos, N. Google Scholar
Rizzo, L. V. Google Scholar
Institution Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Fdn Zerbini
Brazilian Minist Sci & Technol
Abstract The development of microchimerism was evaluated at different time points after infusion of a mixed population of bone marrow and spleen cells from (BALB/c x C57B1/6)F1 mice in the presence or absence of a cardiac transplant. Microchimerism was observed in the spleen, bone marrow and thymus of transplanted BALB/c mice even after graft rejection. in the absence of transplantation, donor cells persisted especially in the thymus. the results show that despite augmentation of graft survival after donor cell infusion compared to nontreated controls, the development of microchimerism did not sustain cardiac semihistocompatible grafts. Moreover, the persistence of donor cells in the thymus in both situations suggests a role for this organ in the increased graft survival in our model.
Language English
Date 2004-05-01
Published in Transplantation Proceedings. New York: Elsevier B.V., v. 36, n. 4, p. 1021-1022, 2004.
ISSN 0041-1345 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 1021-1022
Origin http://dx.doi.org/10.1016/j.transproceed.2004.03.053
Access rights Closed access
Type Article
Web of Science ID WOS:000222063800080
URI http://repositorio.unifesp.br/handle/11600/27742

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