Microchimerism does not correlate with survival of murine cardiac allografts

Microchimerism does not correlate with survival of murine cardiac allografts

Autor Moraes, L. V. de Google Scholar
Bueno, V Google Scholar
Panajotopoulos, N. Google Scholar
Rizzo, L. V. Google Scholar
Instituição Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Fdn Zerbini
Brazilian Minist Sci & Technol
Resumo The development of microchimerism was evaluated at different time points after infusion of a mixed population of bone marrow and spleen cells from (BALB/c x C57B1/6)F1 mice in the presence or absence of a cardiac transplant. Microchimerism was observed in the spleen, bone marrow and thymus of transplanted BALB/c mice even after graft rejection. in the absence of transplantation, donor cells persisted especially in the thymus. the results show that despite augmentation of graft survival after donor cell infusion compared to nontreated controls, the development of microchimerism did not sustain cardiac semihistocompatible grafts. Moreover, the persistence of donor cells in the thymus in both situations suggests a role for this organ in the increased graft survival in our model.
Idioma Inglês
Data de publicação 2004-05-01
Publicado em Transplantation Proceedings. New York: Elsevier B.V., v. 36, n. 4, p. 1021-1022, 2004.
ISSN 0041-1345 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 1021-1022
Fonte http://dx.doi.org/10.1016/j.transproceed.2004.03.053
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000222063800080
Endereço permanente http://repositorio.unifesp.br/handle/11600/27742

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