Role of hippocampal oxidative stress in memory deficits induced by sleep deprivation in mice

Role of hippocampal oxidative stress in memory deficits induced by sleep deprivation in mice

Autor Silva, R. H. Google Scholar
Abilio, V. C. Google Scholar
Takatsu, A. L. Google Scholar
Kameda, SR Google Scholar
Grassl, C. Google Scholar
Chehin, A. B. Google Scholar
Medrano, W. A. Google Scholar
Calzavara, M. B. Google Scholar
Registro, S. Google Scholar
Andersen, M. L. Google Scholar
Machado, R. B. Google Scholar
Carvalho, R. C. Google Scholar
Ribeiro, R. D. Google Scholar
Tufik, S. Google Scholar
Frussa, R. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Numerous animal and clinical studies have described memory deficits following sleep deprivation. There is also evidence that the absence of sleep increases brain oxidative stress. the present study investigates the role of hippocampal oxidative stress in memory deficits induced by sleep deprivation in mice. Mice were sleep deprived for 72 h by the multiple platform method-groups of 4-6 animals were placed in water tanks, containing 12 platforms (3 cm in diameter) Surrounded by water up to 1 cm beneath the surface. Mice kept in their home cage or placed onto larger platforms were used as Control groups. the results showed that hippocampal oxidized/reduced glutathione ratio as well as lipid peroxidation of sleep-deprived mice was significantly increased compared to control groups. the same procedure of sleep deprivation led to a passive avoidance retention deficit. Both passive avoidance retention deficit and increased hippocampal lipid peroxidation were prevented by repeated treatment (15 consecutive days. i.p.) with the antioxidant agents melatonin (5 mg/kg). N-tert-butyl-alpha-phenylnitrone (200 mg/kg) or vitamin E (40 mg/kg). the results indicate an important role of hippocampal oxidative Stress in passive avoidance memory deficits induced by sleep deprivation in mice. (C) 2004 Elsevier B.V. All rights reserved.
Palavra-chave sleep deprivation
memory
oxidative stress
mice
Idioma Inglês
Data de publicação 2004-05-01
Publicado em Neuropharmacology. Oxford: Pergamon-Elsevier B.V., v. 46, n. 6, p. 895-903, 2004.
ISSN 0028-3908 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 895-903
Fonte http://dx.doi.org/10.1016/j.neuropharm.2003.11.032
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000221040200014
Endereço permanente http://repositorio.unifesp.br/handle/11600/27734

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