Comparative study of MMP-2 (matrix metalloproteinase 2) immune expression in normal uterine cervix, intraepithelial neoplasias, and squamous cells cervical carcinoma

Comparative study of MMP-2 (matrix metalloproteinase 2) immune expression in normal uterine cervix, intraepithelial neoplasias, and squamous cells cervical carcinoma

Author Gaiotto, MAM Google Scholar
Focchi, J. Google Scholar
Ribalta, JLC Google Scholar
Stavale, J. N. Google Scholar
Baracat, E. C. Google Scholar
Lima, G. R. Google Scholar
Silva, IDCG da Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Objective: This study was undertaken to evaluate the levels of matrix metalloproteinase 2 (MMP2) in the precursors lesions and in the invasive cervical carcinoma and to quantify the immune reactive expression of MMP-2, using MMP-2 immunohistochemistry, in intraepithelial cervical neoplasias and in the invading cervical carcinoma. Study design: We evaluated 60 samples of cervical tissues using immunohistochemistry for MMP2 in 5 distinct groups. the groups were divided in control, cervical intraepithelial neoplasia I (CIN I), CIN II, CIN III, and cervical invading carcinoma. Results: MMP-2 expression was found gradually increased according to the degree of cervical intraepithelial neoplasia and cervical carcinoma. (Control < CIN I < CIN II < CIN III < Carcinoma) Conclusion: Our results suggest that the expression of MMP-2 can distinguish CIN I, II, and III grades and the invading carcinoma. (C) 2004 Elsevier Inc. All rights reserved.
Keywords metalloproteinases
cervical intraepithelial neoplasia
cervical squamous cell carcinoma
Language English
Date 2004-05-01
Published in American Journal of Obstetrics and Gynecology. St Louis: Mosby, Inc, v. 190, n. 5, p. 1278-1282, 2004.
ISSN 0002-9378 (Sherpa/Romeo, impact factor)
Publisher Mosby, Inc
Extent 1278-1282
Origin http://dx.doi.org/10.1016/j.ajog.2003.12.017
Access rights Closed access
Type Article
Web of Science ID WOS:000221825100019
URI http://repositorio.unifesp.br/handle/11600/27726

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