Angiogenesis and skin carcinomas with skull base invasion: A case-control study

Angiogenesis and skin carcinomas with skull base invasion: A case-control study

Author Cernea, C. R. Google Scholar
Ferraz, A. R. Google Scholar
Castro, IV de Google Scholar
Sotto, M. N. Google Scholar
Logullo, A. F. Google Scholar
Bacchi, C. E. Google Scholar
Potenza, A. S. Google Scholar
Institution Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Abstract Background. Some skin carcinomas may be very aggressive. Intensity of angiogenesis, measured by intratumoral vessel density using expression of CD34, has been associated with tumor aggressiveness. in this study, the expression of CD34 in basal cell carcinomas (BCCs) and squamous cell carcinomas (SCCs) with skull base invasion was compared with that in tumors with good outcome.Methods. Expression of CD34 was graded as mild, moderate, and intense, in 24 BCCs and 11 SCCs with skull base invasion. the control group included 23 BCCs and 10 SCCs.Results. Intense expression of CD34 was noted in 25.00% of BCCs with skull base invasion, compared with 4.35% in the control group (p =.058). Regarding SCCs, intense expression of CD34 was found in 54.55% of aggressive tumors, compared with 10.00% in the control group (p = 133).Conclusions. A trend toward denser microvascular angiogenesis was observed in both BCCs and SCCs with skull base invasion compared with less aggressive controls. (C) 2004 Wiley Periodicals, Inc.
Keywords angiogenesis
basal cell carcinoma
squamous cell carcinoma
base of skull
immunohistochemistry
Language English
Date 2004-05-01
Published in Head and Neck-Journal for the Sciences and Specialties of the Head and Neck. Hoboken: John Wiley & Sons Inc, v. 26, n. 5, p. 396-400, 2004.
ISSN 1043-3074 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 396-400
Origin http://dx.doi.org/10.1002/hed.10399
Access rights Closed access
Type Article
Web of Science ID WOS:000221236600002
URI http://repositorio.unifesp.br/handle/11600/27722

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