Polymorphic Alu insertions in six Brazilian African-derived populations

Polymorphic Alu insertions in six Brazilian African-derived populations

Autor Cotrim, N. H. Google Scholar
Auricchio, MTBM Google Scholar
Vicente, J. P. Google Scholar
Otto, P. A. Google Scholar
Mingroni-Netto, R. C. Google Scholar
Instituição Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Resumo At least 25 African-derived populations (quilombo remnants) are believed to exist in the Ribeira River Valley, located in the southern part of S (a) over tildeo Paulo State, Brazil. We studied four Alu polymorphic loci (APO, ACE, TPA25, and FXIIIB) in individuals belonging to six quilombo remnants in addition to individuals sampled from the city of S (a) over tildeo Paulo. the allelic frequencies observed in the quilombo remnants were similar to those previously observed in African-derived populations from Central and North America. Genetic variability indexes (F(st) and G(st) values) in our quilombos were higher than the reported values for the majority of other populations analyzed for the same kind of markers, but lower than the variability usually observed in Amerindian groups. the observed high degree of genetic differentiation may be due to genetic drift, especially the founder effect. Our results suggest that these populations behave genetically as semi-isolates. the degree of genetic variability within populations was larger than among them, a finding described in other studies. in the neighbor-joining tree, some of the Brazilian quilombos clustered with the African and African-derived populations (S (a) over tildeo Pedro and Galv (a) over tildeo), others with the Europeans (Pil (o) over tilde es, Maria Rosa, and Abobral). Pedro Cubas was placed in an isolated branch. Principal component analysis was also performed and confirmed the trends observed in the neighbor-joining tree. Overall, the quilombos showed a higher degree of gene flow than average when compared to other worldwide populations, but similar to other African-derived populations. (C) 2004 Wiley-Liss, Inc.
Idioma Inglês
Data de publicação 2004-05-01
Publicado em American Journal of Human Biology. Malden: Wiley-Blackwell, v. 16, n. 3, p. 264-277, 2004.
ISSN 1042-0533 (Sherpa/Romeo, fator de impacto)
Publicador Wiley-Blackwell
Extensão 264-277
Fonte http://dx.doi.org/10.1002/ajhb.20024
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000221041700002
Endereço permanente http://repositorio.unifesp.br/handle/11600/27721

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