An imbalance of naive and memory/effector subsets and altered expression of CD38 on T lymphocytes in two girls with hyper-IgM syndrome

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dc.contributor.author Costa-Carvalho, Beatriz Tavares [UNIFESP]
dc.contributor.author Viana, M. A.
dc.contributor.author Brunialti, Milena Karina Coló [UNIFESP]
dc.contributor.author Kallas, Esper Georges [UNIFESP]
dc.contributor.author Salomão, Reinaldo [UNIFESP]
dc.date.accessioned 2016-01-24T12:37:07Z
dc.date.available 2016-01-24T12:37:07Z
dc.date.issued 2004-05-01
dc.identifier http://dx.doi.org/10.1111/j.1365-2249.2004.02446.x
dc.identifier.citation Clinical and Experimental Immunology. Oxford: Blackwell Publishing Ltd, v. 136, n. 2, p. 291-296, 2004.
dc.identifier.issn 0009-9104
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/27719
dc.description.abstract In this report we evaluated CD4(+) T, CD8(+) T and natural killer (NK) cell counts, the levels of naive/memory subsets within the CD4(+) T lymphocyte population, expression of CD38 on T lymphocytes, and CD4(+) and CD8(+) T cell cytokine production in two girls with hyper-IgM (HIM) syndrome. Both girls developed recurrent infections early in infancy, presenting a wide spectrum of clinical manifestations, with a strikingly different disease severity between them. CD4(+) T cell counts were low in both children (patient 1: 214 cells/mm(3) and patient 2: 392 cells/mm(3)), and the CD4/CD8 T cell ratio was 0.4 for patient 1, the patient with the more severe disease, and 1.4 for patient 2. NK cell numbers were low in patient 1 (60 cells/mm(3)) and borderline (286 cells/mm(3)) with regard to normal levels in patient 2. An imbalance of naive and memory/effector cell subsets was found in both girls, with the percentage of CD45RA(+) 27(+) (naive) CD4(+) T lymphocytes being 5.8 and 12.4 for patients 1 and 2, respectively. Expression of CD38 on the surface of T lymphocytes was low in patient 1. Detection of intracellular interferon (IFN)-gamma and tumour necrosis factor (TNF)-alpha in CD4(+) and CD8(+) T lymphocytes upon PMA-Io stimulus was preserved in both children. in conclusion, we found low numbers of CD4(+) T lymphocytes and a dramatic redistribution of naive and memory/effector CD4(+) T lymphocytes in two girls with non-X-linked HIM syndrome. Furthermore, we found low expression of CD38 on T lymphocytes and low numbers of NK cells in the patient with the more severe disease, indicating a possible role for these cells in the pathogenesis of this immunodeficiency. en
dc.format.extent 291-296
dc.language.iso eng
dc.publisher Blackwell Publishing Ltd
dc.relation.ispartof Clinical and Experimental Immunology
dc.rights Acesso aberto
dc.subject CD38 en
dc.subject cytokines en
dc.subject hyper-IgM en
dc.subject naive/memory cells en
dc.subject T lymphocytes en
dc.title An imbalance of naive and memory/effector subsets and altered expression of CD38 on T lymphocytes in two girls with hyper-IgM syndrome en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo, Div Infect Dis, UNIFESP, Immunol Lab, BR-04039032 São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Pediat, Div Rheumatol Allergy & Clin Immunol, BR-04039032 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Div Infect Dis, UNIFESP, Immunol Lab, BR-04039032 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Pediat, Div Rheumatol Allergy & Clin Immunol, BR-04039032 São Paulo, Brazil
dc.identifier.doi 10.1111/j.1365-2249.2004.02446.x
dc.description.source Web of Science
dc.identifier.wos WOS:000220736600015



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