The synthesis and distribution of the kinin B1 and B2 receptors are modified in the hippocampus of rats submitted to pilocarpine model of epilepsy

Mostrar registro simples

dc.contributor.author Arganaraz, G. A.
dc.contributor.author Silva, J. A.
dc.contributor.author Perosa, SR
dc.contributor.author Pessoa, L. G.
dc.contributor.author Carvalho, F. F.
dc.contributor.author Bascands, J. L.
dc.contributor.author Bader, M.
dc.contributor.author Trindade, E. D.
dc.contributor.author Amado, D.
dc.contributor.author Cavalheiro, E. A.
dc.contributor.author Pesquero, J. B.
dc.contributor.author Naffah-Mazzacoratti, M. D.
dc.date.accessioned 2016-01-24T12:37:06Z
dc.date.available 2016-01-24T12:37:06Z
dc.date.issued 2004-04-23
dc.identifier http://dx.doi.org/10.1016/j.brainres.2003.12.050
dc.identifier.citation Brain Research. Amsterdam: Elsevier B.V., v. 1006, n. 1, p. 114-125, 2004.
dc.identifier.issn 0006-8993
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/27711
dc.description.abstract Kinins, a special class of polypeptides, are represented by bradykinin (BK), kallidin (Lys-BK), as well as their metabolites. the biological actions of these polypeptides binding on their receptors (B1 and B2) have been related to inflammation process, cytokines action, glutamate release and prostaglandins production. Usually, kinin B1 receptor is not expressed at a significant level under physiologic conditions in most tissues, but its expression is induced by injury, or upon exposure in vivo or in vitro to pro-inflammatory mediators. the kinin B2 receptor subtype is constitutively and widely expressed throughout the central and peripheral nervous system. These data raise the possibility for de novo expression of those receptors during the temporal lobe epilepsy (TLE), which has been related to cell death, gliosis and hippocampal reorganization. To correlate kinin system and TLE, adult male Wistar rats were submitted to pilocarpine model of epilepsy. the hippocampi were removed 6 h, 5 and 60 days after status epilepticus (SE) onset. the collected tissues were used to study the expression of kinin B1 and B2 mRNA receptors, using Real-Time PCR. Immunohistochemistry assay was also employed to visualize kinin B1 and B2 distribution in the hippocampus. the results show increased kinin B1 and B2 mRNA levels during acute, silent and chronic periods and changes in the kinin B1 and B2 receptors distribution. in addition, the immunoreactivity against kinin B1 receptor was increased mainly during the silent period, where neuron clusters of could be visualized. the kinin B2 receptor immunoreactivity also showed augmentation but mainly during the acute and silent periods. Our results suggest that kinin B1 and B2 receptors play an important role in the epileptic phenomena. (C) 2004 Elsevier B.V. All rights reserved. en
dc.format.extent 114-125
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Brain Research
dc.rights Acesso restrito
dc.subject kinin B1 and B2 receptors en
dc.subject temporal lobe epilepsy en
dc.subject pilocarpine en
dc.subject hippocampus en
dc.subject plasticity en
dc.subject Status epilepticus en
dc.title The synthesis and distribution of the kinin B1 and B2 receptors are modified in the hippocampus of rats submitted to pilocarpine model of epilepsy en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Universidade Federal do Rio de Janeiro (UFRJ)
dc.contributor.institution Fac Med Toulouse
dc.contributor.institution Max Delbruck Ctr
dc.description.affiliation Universidade Federal de São Paulo, Dept Neurol Neurocirurgia, São Paulo, Brazil
dc.description.affiliation UFRJ, Inst Biofis Carlos Chagas Filho, Rio de Janeiro, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Biofis, São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Patol, São Paulo, Brazil
dc.description.affiliation Fac Med Toulouse, INSERM, F-31073 Toulouse, France
dc.description.affiliation Max Delbruck Ctr, Berlin, Germany
dc.description.affiliation Universidade Federal de São Paulo, Dept Bioquim, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Neurol Neurocirurgia, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Biofis, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Patol, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Bioquim, São Paulo, Brazil
dc.identifier.doi 10.1016/j.brainres.2003.12.050
dc.description.source Web of Science
dc.identifier.wos WOS:000220822400013



Arquivos deste item

Arquivos Tamanho Formato Visualização

Não existem arquivos associados a este item.

Este item aparece na(s) seguinte(s) coleção(s)

Mostrar registro simples